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@ARTICLE{Madhavan:129103,
      author       = {D. Madhavan$^*$ and C. Peng$^*$ and M. Wallwiener and M.
                      Zucknick$^*$ and J. Nees and S. Schott and A. Rudolph$^*$
                      and S. Riethdorf and A. Trumpp$^*$ and K. Pantel and C. Sohn
                      and J. Chang-Claude$^*$ and A. Schneeweiss and B.
                      Burwinkel$^*$},
      title        = {{C}irculating mi{RNA}s with prognostic value in metastatic
                      breast cancer and for early detection of metastasis.},
      journal      = {Carcinogenesis},
      volume       = {37},
      number       = {5},
      issn         = {1460-2180},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DKFZ-2017-05108},
      pages        = {461 - 470},
      year         = {2016},
      abstract     = {Metastasis is the principal cause of high morbidity and
                      mortality among breast cancer (BC) patients. Identification
                      of markers that can be routinely monitored to predict onset
                      of metastasis in BC patients and prognosis of metastatic
                      breast cancer (MBC) patients would increase their median
                      survival. In this study, plasma miRNAs of 40 MBC patients
                      were profiled by TaqMan low density arrays and miRNAs with
                      prognostic capacity were identified. The candidates were
                      validated initially in the samples of 237 MBC patients and
                      subsequently in 335 samples from an independent study cohort
                      of BC patients. Sixteen miRNAs were established to be
                      significantly associated with overall survival, and were
                      termed as prognostic miRNA panel template (PROMPT). These
                      included miR-141, miR-144, miR-193b, miR-200a, miR-200b,
                      miR-200c, miR-203, miR-210, miR-215, miR-365, miR-375,
                      miR-429, miR-486-5p, miR-801, miR-1260 and miR-1274a.
                      Additionally, 11 of these miRNAs were also associated with
                      progression-free survival. Their prognostic significance was
                      further confirmed in samples from a second study cohort of
                      BC patients. In addition, miR-200a, miR-200b, miR-200c,
                      miR-210, miR-215 and miR-486-5p were found to be
                      significantly associated with onset of metastasis up to 2
                      years prior to clinical diagnosis in BC patients. We have
                      thus identified panels of miRNAs, which include metastasis
                      promoting miR-200 family and miR-203, as well as oncogenic
                      and tumor-suppressive miRNAs, that can serve as prognostic
                      markers for MBC, and early detection markers of metastasis
                      in BC.},
      keywords     = {Biomarkers, Tumor (NLM Chemicals) / MicroRNAs (NLM
                      Chemicals)},
      cin          = {C080 / C020 / A010 / C060},
      ddc          = {610},
      cid          = {I:(DE-He78)C080-20160331 / I:(DE-He78)C020-20160331 /
                      I:(DE-He78)A010-20160331 / I:(DE-He78)C060-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26785733},
      doi          = {10.1093/carcin/bgw008},
      url          = {https://inrepo02.dkfz.de/record/129103},
}