Journal Article

DKFZ-2017-05108

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Circulating miRNAs with prognostic value in metastatic breast cancer and for early detection of metastasis.

Madhavan, D. (First author)DKFZ* ; Peng, C.DKFZ* ; Wallwiener, M. ; Zucknick, M.DKFZ* ; Nees, J. ; Schott, S. ; Rudolph, A.DKFZ* ; Riethdorf, S. ; Trumpp, A.DKFZ* ; Pantel, K. ; Sohn, C. ; Chang-Claude, J.DKFZ* ; Schneeweiss, A. ; Burwinkel, B. (Last author)DKFZ*

2016
Oxford Univ. Press Oxford

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Please use a persistent id in citations: doi:10.1093/carcin/bgw008

Abstract: Metastasis is the principal cause of high morbidity and mortality among breast cancer (BC) patients. Identification of markers that can be routinely monitored to predict onset of metastasis in BC patients and prognosis of metastatic breast cancer (MBC) patients would increase their median survival. In this study, plasma miRNAs of 40 MBC patients were profiled by TaqMan low density arrays and miRNAs with prognostic capacity were identified. The candidates were validated initially in the samples of 237 MBC patients and subsequently in 335 samples from an independent study cohort of BC patients. Sixteen miRNAs were established to be significantly associated with overall survival, and were termed as prognostic miRNA panel template (PROMPT). These included miR-141, miR-144, miR-193b, miR-200a, miR-200b, miR-200c, miR-203, miR-210, miR-215, miR-365, miR-375, miR-429, miR-486-5p, miR-801, miR-1260 and miR-1274a. Additionally, 11 of these miRNAs were also associated with progression-free survival. Their prognostic significance was further confirmed in samples from a second study cohort of BC patients. In addition, miR-200a, miR-200b, miR-200c, miR-210, miR-215 and miR-486-5p were found to be significantly associated with onset of metastasis up to 2 years prior to clinical diagnosis in BC patients. We have thus identified panels of miRNAs, which include metastasis promoting miR-200 family and miR-203, as well as oncogenic and tumor-suppressive miRNAs, that can serve as prognostic markers for MBC, and early detection markers of metastasis in BC.

Keyword(s): Biomarkers, Tumor ; MicroRNAs

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Contributing Institute(s):

1. Molekulare Epidemiologie (C080)
2. Epidemiologie von Krebserkrankungen (C020)
3. Stammzellen und Krebs (A010)
4. Biostatistik (C060)

Research Program(s):

1. 313 - Cancer risk factors and prevention (POF3-313) (POF3-313)

Appears in the scientific report 2016

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Database coverage:
; Allianz-Lizenz / DFG ; BIOSIS Previews ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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