Journal Article

DKFZ-2017-05114

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Biologically optimized helium ion plans: calculation approach and its in vitro validation.

Mairani, A. ; Dokic, I.DKFZ* ; Magro, G. ; Tessonnier, T. ; Kamp, F. ; Carlson, D. J. ; Ciocca, M. ; Cerutti, F. ; Sala, P. R. ; Ferrari, A. ; Böhlen, T. T. ; Jäkel, O.DKFZ* ; Parodi, K.DKFZ* ; Debus, J.DKFZ* ; Abdollahi, A.DKFZ* ; Haberer, T.

2016
IOP Publ. Bristol

This record in other databases:

Please use a persistent id in citations: doi:10.1088/0031-9155/61/11/4283

Abstract: Treatment planning studies on the biological effect of raster-scanned helium ion beams should be performed, together with their experimental verification, before their clinical application at the Heidelberg Ion Beam Therapy Center (HIT). For this purpose, we introduce a novel calculation approach based on integrating data-driven biological models in our Monte Carlo treatment planning (MCTP) tool. Dealing with a mixed radiation field, the biological effect of the primary (4)He ion beams, of the secondary (3)He and (4)He (Z  =  2) fragments and of the produced protons, deuterons and tritons (Z  =  1) has to be taken into account. A spread-out Bragg peak (SOBP) in water, representative of a clinically-relevant scenario, has been biologically optimized with the MCTP and then delivered at HIT. Predictions of cell survival and RBE for a tumor cell line, characterized by [Formula: see text] Gy, have been successfully compared against measured clonogenic survival data. The mean absolute survival variation ([Formula: see text]) between model predictions and experimental data was 5.3%  ±  0.9%. A sensitivity study, i.e. quantifying the variation of the estimations for the studied plan as a function of the applied phenomenological modelling approach, has been performed. The feasibility of a simpler biological modelling based on dose-averaged LET (linear energy transfer) has been tested. Moreover, comparisons with biophysical models such as the local effect model (LEM) and the repair-misrepair-fixation (RMF) model were performed. [Formula: see text] values for the LEM and the RMF model were, respectively, 4.5%  ±  0.8% and 5.8%  ±  1.1%. The satisfactorily agreement found in this work for the studied SOBP, representative of clinically-relevant scenario, suggests that the introduced approach could be applied for an accurate estimation of the biological effect for helium ion radiotherapy.

Keyword(s): Radioisotopes ; Helium

---

Contributing Institute(s):

1. Translationale Radioonkologie (E210)
2. Medizinische Physik in der Strahlentherapie (E040)
3. DKTK Heidelberg (L101)

Research Program(s):

1. 315 - Imaging and radiooncology (POF3-315) (POF3-315)

Appears in the scientific report 2016

---

Database coverage:
; BIOSIS Previews ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; National-Konsortium ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

---