TY  - JOUR
AU  - Thomas, Christian
AU  - Sill, Martin
AU  - Ruland, Vincent
AU  - Witten, Anika
AU  - Hartung, Stefan
AU  - Kordes, Uwe
AU  - Jeibmann, Astrid
AU  - Beschorner, Rudi
AU  - Keyvani, Kathy
AU  - Bergmann, Markus
AU  - Mittelbronn, Michel
AU  - Pietsch, Torsten
AU  - Felsberg, Jörg
AU  - Monoranu, Camelia M
AU  - Varlet, Pascale
AU  - Hauser, Peter
AU  - Olar, Adriana
AU  - Grundy, Richard G
AU  - Wolff, Johannes E
AU  - Korshunov, Andrey
AU  - Jones, David
AU  - Bewerunge-Hudler, Melanie
AU  - Hovestadt, Volker
AU  - von Deimling, Andreas
AU  - Pfister, Stefan
AU  - Paulus, Werner
AU  - Capper, David
AU  - Hasselblatt, Martin
TI  - Methylation profiling of choroid plexus tumors reveals 3 clinically distinct subgroups.
JO  - Neuro-Oncology
VL  - 18
IS  - 6
SN  - 1523-5866
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DKFZ-2017-05747
SP  - 790 - 796
PY  - 2016
AB  - Choroid plexus tumors are intraventricular neoplasms derived from the choroid plexus epithelium. A better knowledge of molecular factors involved in choroid plexus tumor biology may aid in identifying patients at risk for recurrence.Methylation profiles were examined in 29 choroid plexus papillomas (CPPs, WHO grade I), 32 atypical choroid plexus papillomas (aCPPs, WHO grade II), and 31 choroid plexus carcinomas (CPCs, WHO grade III) by Illumina Infinium HumanMethylation450 Bead Chip Array.Unsupervised hierarchical clustering identified 3 subgroups: methylation cluster 1 (pediatric CPP and aCPP of mainly supratentorial location), methylation cluster 2 (adult CPP and aCPP of mainly infratentorial location), and methylation cluster 3 (pediatric CPP, aCPP, and CPC of supratentorial location). In methylation cluster 3, progression-free survival (PFS) accounted for a mean of 72 months (CI, 55-89 mo), whereas only 1 of 42 tumors of methylation clusters 1 and 2 progressed (P< .001). On stratification of outcome data according to WHO grade, all CPCs clustered within cluster 3 and were associated with shorter overall survival (mean, 105 mo [CI, 81-128 mo]) and PFS (mean, 55 mo [CI, 36-73 mo]). The aCPP of methylation cluster 3 also progressed frequently (mean, 69 mo [CI, 44-93 mo]), whereas no tumor progression was observed in aCPP of methylation clusters 1 and 2 (P< .05). Only 1 of 29 CPPs recurred.Methylation profiling of choroid plexus tumors reveals 3 distinct subgroups (ie, pediatric low-risk choroid plexus tumors [cluster 1], adult low-risk choroid plexus tumors [cluster 2], and pediatric high-risk choroid plexus tumors [cluster 3]) and may provide useful prognostic information in addition to histopathology.
LB  - PUB:(DE-HGF)16
C6  - pmid:26826203
C2  - pmc:PMC4864264
DO  - DOI:10.1093/neuonc/nov322
UR  - https://inrepo02.dkfz.de/record/130669
ER  -