Journal Article

DKFZ-2017-05747

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Methylation profiling of choroid plexus tumors reveals 3 clinically distinct subgroups.

Thomas, C. ; Sill, M.DKFZ* ; Ruland, V. ; Witten, A. ; Hartung, S. ; Kordes, U. ; Jeibmann, A. ; Beschorner, R. ; Keyvani, K. ; Bergmann, M. ; Mittelbronn, M.DKFZ* ; Pietsch, T. ; Felsberg, J. ; Monoranu, C. M. ; Varlet, P. ; Hauser, P. ; Olar, A. ; Grundy, R. G. ; Wolff, J. E. ; Korshunov, A.DKFZ* ; Jones, D.DKFZ* ; Bewerunge-Hudler, M.DKFZ* ; Hovestadt, V.DKFZ* ; von Deimling, A. ; Pfister, S.DKFZ* ; Paulus, W. ; Capper, D.DKFZ* ; Hasselblatt, M.

2016
Oxford Univ. Press Oxford

This record in other databases:  

Please use a persistent id in citations: doi:10.1093/neuonc/nov322

Abstract: Choroid plexus tumors are intraventricular neoplasms derived from the choroid plexus epithelium. A better knowledge of molecular factors involved in choroid plexus tumor biology may aid in identifying patients at risk for recurrence.Methylation profiles were examined in 29 choroid plexus papillomas (CPPs, WHO grade I), 32 atypical choroid plexus papillomas (aCPPs, WHO grade II), and 31 choroid plexus carcinomas (CPCs, WHO grade III) by Illumina Infinium HumanMethylation450 Bead Chip Array.Unsupervised hierarchical clustering identified 3 subgroups: methylation cluster 1 (pediatric CPP and aCPP of mainly supratentorial location), methylation cluster 2 (adult CPP and aCPP of mainly infratentorial location), and methylation cluster 3 (pediatric CPP, aCPP, and CPC of supratentorial location). In methylation cluster 3, progression-free survival (PFS) accounted for a mean of 72 months (CI, 55-89 mo), whereas only 1 of 42 tumors of methylation clusters 1 and 2 progressed (P< .001). On stratification of outcome data according to WHO grade, all CPCs clustered within cluster 3 and were associated with shorter overall survival (mean, 105 mo [CI, 81-128 mo]) and PFS (mean, 55 mo [CI, 36-73 mo]). The aCPP of methylation cluster 3 also progressed frequently (mean, 69 mo [CI, 44-93 mo]), whereas no tumor progression was observed in aCPP of methylation clusters 1 and 2 (P< .05). Only 1 of 29 CPPs recurred.Methylation profiling of choroid plexus tumors reveals 3 distinct subgroups (ie, pediatric low-risk choroid plexus tumors [cluster 1], adult low-risk choroid plexus tumors [cluster 2], and pediatric high-risk choroid plexus tumors [cluster 3]) and may provide useful prognostic information in addition to histopathology.

---

Contributing Institute(s):

1. Biostatistik (C060)
2. KKE Neuropathologie (G380)
3. Pädiatrische Neuroonkologie (B062)
4. Microarray Unit (W110)
5. Molekulare Genetik (B060)
6. DKTK Heidelberg (L101)
7. DKTK Frankfurt (L501)

Research Program(s):

1. 312 - Functional and structural genomics (POF3-312) (POF3-312)

Appears in the scientific report 2016

---

Database coverage:
; Allianz-Lizenz / DFG ; Current Contents - Clinical Medicine ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

---