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@ARTICLE{Thomas:130669,
      author       = {C. Thomas and M. Sill$^*$ and V. Ruland and A. Witten and
                      S. Hartung and U. Kordes and A. Jeibmann and R. Beschorner
                      and K. Keyvani and M. Bergmann and M. Mittelbronn$^*$ and T.
                      Pietsch and J. Felsberg and C. M. Monoranu and P. Varlet and
                      P. Hauser and A. Olar and R. G. Grundy and J. E. Wolff and
                      A. Korshunov$^*$ and D. Jones$^*$ and M.
                      Bewerunge-Hudler$^*$ and V. Hovestadt$^*$ and A. von
                      Deimling and S. Pfister$^*$ and W. Paulus and D. Capper$^*$
                      and M. Hasselblatt},
      title        = {{M}ethylation profiling of choroid plexus tumors reveals 3
                      clinically distinct subgroups.},
      journal      = {Neuro-Oncology},
      volume       = {18},
      number       = {6},
      issn         = {1523-5866},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DKFZ-2017-05747},
      pages        = {790 - 796},
      year         = {2016},
      abstract     = {Choroid plexus tumors are intraventricular neoplasms
                      derived from the choroid plexus epithelium. A better
                      knowledge of molecular factors involved in choroid plexus
                      tumor biology may aid in identifying patients at risk for
                      recurrence.Methylation profiles were examined in 29 choroid
                      plexus papillomas (CPPs, WHO grade I), 32 atypical choroid
                      plexus papillomas (aCPPs, WHO grade II), and 31 choroid
                      plexus carcinomas (CPCs, WHO grade III) by Illumina Infinium
                      HumanMethylation450 Bead Chip Array.Unsupervised
                      hierarchical clustering identified 3 subgroups: methylation
                      cluster 1 (pediatric CPP and aCPP of mainly supratentorial
                      location), methylation cluster 2 (adult CPP and aCPP of
                      mainly infratentorial location), and methylation cluster 3
                      (pediatric CPP, aCPP, and CPC of supratentorial location).
                      In methylation cluster 3, progression-free survival (PFS)
                      accounted for a mean of 72 months (CI, 55-89 mo), whereas
                      only 1 of 42 tumors of methylation clusters 1 and 2
                      progressed (P< .001). On stratification of outcome data
                      according to WHO grade, all CPCs clustered within cluster 3
                      and were associated with shorter overall survival (mean, 105
                      mo [CI, 81-128 mo]) and PFS (mean, 55 mo [CI, 36-73 mo]).
                      The aCPP of methylation cluster 3 also progressed frequently
                      (mean, 69 mo [CI, 44-93 mo]), whereas no tumor progression
                      was observed in aCPP of methylation clusters 1 and 2 (P<
                      .05). Only 1 of 29 CPPs recurred.Methylation profiling of
                      choroid plexus tumors reveals 3 distinct subgroups (ie,
                      pediatric low-risk choroid plexus tumors [cluster 1], adult
                      low-risk choroid plexus tumors [cluster 2], and pediatric
                      high-risk choroid plexus tumors [cluster 3]) and may provide
                      useful prognostic information in addition to
                      histopathology.},
      cin          = {C060 / G380 / B062 / W110 / B060 / L101 / L501},
      ddc          = {610},
      cid          = {I:(DE-He78)C060-20160331 / I:(DE-He78)G380-20160331 /
                      I:(DE-He78)B062-20160331 / I:(DE-He78)W110-20160331 /
                      I:(DE-He78)B060-20160331 / I:(DE-He78)L101-20160331 /
                      I:(DE-He78)L501-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26826203},
      pmc          = {pmc:PMC4864264},
      doi          = {10.1093/neuonc/nov322},
      url          = {https://inrepo02.dkfz.de/record/130669},
}