TY  - JOUR
AU  - Vo, BaoHan T
AU  - Wolf, Elmar
AU  - Kawauchi, Daisuke
AU  - Gebhardt, Anneli
AU  - Rehg, Jerold E
AU  - Finkelstein, David
AU  - Walz, Susanne
AU  - Murphy, Brian L
AU  - Youn, Yong Ha
AU  - Han, Young-Goo
AU  - Eilers, Martin
AU  - Roussel, Martine F
TI  - The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity.
JO  - Cancer cell
VL  - 29
IS  - 1
SN  - 1535-6108
CY  - Cambridge, Mass.
PB  - Cell Press
M1  - DKFZ-2017-05810
SP  - 5 - 16
PY  - 2016
AB  - Four distinct subgroups of cerebellar medulloblastomas (MBs) differ in their histopathology, molecular profiles, and prognosis. c-Myc (Myc) or MycN overexpression in granule neuron progenitors (GNPs) induces Group 3 (G3) or Sonic Hedgehog (SHH) MBs, respectively. Differences in Myc and MycN transcriptional profiles depend, in part, on their interaction with Miz1, which binds strongly to Myc but not MycN, to target sites on chromatin. Myc suppresses ciliogenesis and reprograms the transcriptome of SHH-dependent GNPs through Miz1-dependent gene repression to maintain stemness. Genetic disruption of the Myc/Miz1 interaction inhibited G3 MB development. Target genes of Myc/Miz1 are repressed in human G3 MBs but not in other subgroups. Therefore, the Myc/Miz1 interaction is a defining hallmark of G3 MB development.
KW  - Hedgehog Proteins (NLM Chemicals)
KW  - Miz1 protein, mouse (NLM Chemicals)
KW  - Nuclear Proteins (NLM Chemicals)
KW  - Protein Inhibitors of Activated STAT (NLM Chemicals)
KW  - Proto-Oncogene Proteins c-myc (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:26766587
C2  - pmc:PMC4714043
DO  - DOI:10.1016/j.ccell.2015.12.003
UR  - https://inrepo02.dkfz.de/record/130732
ER  -