Journal Article

DKFZ-2017-05810

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity.

Vo, B. T. ; Wolf, E. ; Kawauchi, D.DKFZ* ; Gebhardt, A. ; Rehg, J. E. ; Finkelstein, D. ; Walz, S. ; Murphy, B. L. ; Youn, Y. H. ; Han, Y.-G. ; Eilers, M. ; Roussel, M. F.

2016
Cell Press Cambridge, Mass.

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Please use a persistent id in citations: doi:10.1016/j.ccell.2015.12.003

Abstract: Four distinct subgroups of cerebellar medulloblastomas (MBs) differ in their histopathology, molecular profiles, and prognosis. c-Myc (Myc) or MycN overexpression in granule neuron progenitors (GNPs) induces Group 3 (G3) or Sonic Hedgehog (SHH) MBs, respectively. Differences in Myc and MycN transcriptional profiles depend, in part, on their interaction with Miz1, which binds strongly to Myc but not MycN, to target sites on chromatin. Myc suppresses ciliogenesis and reprograms the transcriptome of SHH-dependent GNPs through Miz1-dependent gene repression to maintain stemness. Genetic disruption of the Myc/Miz1 interaction inhibited G3 MB development. Target genes of Myc/Miz1 are repressed in human G3 MBs but not in other subgroups. Therefore, the Myc/Miz1 interaction is a defining hallmark of G3 MB development.

Keyword(s): Hedgehog Proteins ; Miz1 protein, mouse ; Nuclear Proteins ; Protein Inhibitors of Activated STAT ; Proto-Oncogene Proteins c-myc

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Contributing Institute(s):

1. Pädiatrische Neuroonkologie (B062)

Research Program(s):

1. 312 - Functional and structural genomics (POF3-312) (POF3-312)

Appears in the scientific report 2016

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Database coverage:
; BIOSIS Previews ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 20 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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