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@ARTICLE{Vo:130732,
      author       = {B. T. Vo and E. Wolf and D. Kawauchi$^*$ and A. Gebhardt
                      and J. E. Rehg and D. Finkelstein and S. Walz and B. L.
                      Murphy and Y. H. Youn and Y.-G. Han and M. Eilers and M. F.
                      Roussel},
      title        = {{T}he {I}nteraction of {M}yc with {M}iz1 {D}efines
                      {M}edulloblastoma {S}ubgroup {I}dentity.},
      journal      = {Cancer cell},
      volume       = {29},
      number       = {1},
      issn         = {1535-6108},
      address      = {Cambridge, Mass.},
      publisher    = {Cell Press},
      reportid     = {DKFZ-2017-05810},
      pages        = {5 - 16},
      year         = {2016},
      abstract     = {Four distinct subgroups of cerebellar medulloblastomas
                      (MBs) differ in their histopathology, molecular profiles,
                      and prognosis. c-Myc (Myc) or MycN overexpression in granule
                      neuron progenitors (GNPs) induces Group 3 (G3) or Sonic
                      Hedgehog (SHH) MBs, respectively. Differences in Myc and
                      MycN transcriptional profiles depend, in part, on their
                      interaction with Miz1, which binds strongly to Myc but not
                      MycN, to target sites on chromatin. Myc suppresses
                      ciliogenesis and reprograms the transcriptome of
                      SHH-dependent GNPs through Miz1-dependent gene repression to
                      maintain stemness. Genetic disruption of the Myc/Miz1
                      interaction inhibited G3 MB development. Target genes of
                      Myc/Miz1 are repressed in human G3 MBs but not in other
                      subgroups. Therefore, the Myc/Miz1 interaction is a defining
                      hallmark of G3 MB development.},
      keywords     = {Hedgehog Proteins (NLM Chemicals) / Miz1 protein, mouse
                      (NLM Chemicals) / Nuclear Proteins (NLM Chemicals) / Protein
                      Inhibitors of Activated STAT (NLM Chemicals) /
                      Proto-Oncogene Proteins c-myc (NLM Chemicals)},
      cin          = {B062},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26766587},
      pmc          = {pmc:PMC4714043},
      doi          = {10.1016/j.ccell.2015.12.003},
      url          = {https://inrepo02.dkfz.de/record/130732},
}