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| Home > Publications database > The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity. > print |
| 001 | 130732 | ||
| 005 | 20240228143457.0 | ||
| 024 | 7 | _ | |a 10.1016/j.ccell.2015.12.003 |2 doi |
| 024 | 7 | _ | |a pmid:26766587 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC4714043 |2 pmc |
| 024 | 7 | _ | |a 1535-6108 |2 ISSN |
| 024 | 7 | _ | |a 1878-3686 |2 ISSN |
| 024 | 7 | _ | |a altmetric:4980160 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2017-05810 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Vo, BaoHan T |b 0 |
| 245 | _ | _ | |a The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity. |
| 260 | _ | _ | |a Cambridge, Mass. |c 2016 |b Cell Press |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1522150577_18537 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Four distinct subgroups of cerebellar medulloblastomas (MBs) differ in their histopathology, molecular profiles, and prognosis. c-Myc (Myc) or MycN overexpression in granule neuron progenitors (GNPs) induces Group 3 (G3) or Sonic Hedgehog (SHH) MBs, respectively. Differences in Myc and MycN transcriptional profiles depend, in part, on their interaction with Miz1, which binds strongly to Myc but not MycN, to target sites on chromatin. Myc suppresses ciliogenesis and reprograms the transcriptome of SHH-dependent GNPs through Miz1-dependent gene repression to maintain stemness. Genetic disruption of the Myc/Miz1 interaction inhibited G3 MB development. Target genes of Myc/Miz1 are repressed in human G3 MBs but not in other subgroups. Therefore, the Myc/Miz1 interaction is a defining hallmark of G3 MB development. |
| 536 | _ | _ | |a 312 - Functional and structural genomics (POF3-312) |0 G:(DE-HGF)POF3-312 |c POF3-312 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Hedgehog Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a Miz1 protein, mouse |2 NLM Chemicals |
| 650 | _ | 7 | |a Nuclear Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a Protein Inhibitors of Activated STAT |2 NLM Chemicals |
| 650 | _ | 7 | |a Proto-Oncogene Proteins c-myc |2 NLM Chemicals |
| 700 | 1 | _ | |a Wolf, Elmar |b 1 |
| 700 | 1 | _ | |a Kawauchi, Daisuke |0 P:(DE-He78)0ac2bd1a9fb1823a351ee4434d80808b |b 2 |u dkfz |
| 700 | 1 | _ | |a Gebhardt, Anneli |b 3 |
| 700 | 1 | _ | |a Rehg, Jerold E |b 4 |
| 700 | 1 | _ | |a Finkelstein, David |b 5 |
| 700 | 1 | _ | |a Walz, Susanne |b 6 |
| 700 | 1 | _ | |a Murphy, Brian L |b 7 |
| 700 | 1 | _ | |a Youn, Yong Ha |b 8 |
| 700 | 1 | _ | |a Han, Young-Goo |b 9 |
| 700 | 1 | _ | |a Eilers, Martin |b 10 |
| 700 | 1 | _ | |a Roussel, Martine F |b 11 |
| 773 | _ | _ | |a 10.1016/j.ccell.2015.12.003 |g Vol. 29, no. 1, p. 5 - 16 |0 PERI:(DE-600)2074034-7 |n 1 |p 5 - 16 |t Cancer cell |v 29 |y 2016 |x 1535-6108 |
| 909 | C | O | |o oai:inrepo02.dkfz.de:130732 |p VDB |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 2 |6 P:(DE-He78)0ac2bd1a9fb1823a351ee4434d80808b |
| 913 | 1 | _ | |a DE-HGF |l Krebsforschung |1 G:(DE-HGF)POF3-310 |0 G:(DE-HGF)POF3-312 |2 G:(DE-HGF)POF3-300 |v Functional and structural genomics |x 0 |4 G:(DE-HGF)POF |3 G:(DE-HGF)POF3 |b Gesundheit |
| 914 | 1 | _ | |y 2016 |
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