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000130828 1001_ $$0P:(DE-HGF)0$$aWeber, Claudia E M$$b0$$eFirst author
000130828 245__ $$amiR-339-3p Is a Tumor Suppressor in Melanoma.
000130828 260__ $$aPhiladelphia, Pa.$$bAACR$$c2016
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000130828 520__ $$aDeterminants of invasion and metastasis in cancer remain of great interest to define. Here, we report the definition of miR-339-3p as a novel tumor suppressive microRNA that blocks melanoma cell invasion without affecting cell survival. miR-339-3p was identified by a comprehensive functional screen of a human miRNA mimetic library in a cell-based assay for invasion by the melanoma cell line A375. miR-339-3p was determined as a strong inhibitor of invasion differentially expressed in melanoma cells and healthy melanocytes. MCL1 was defined as a target for downregulation by miR-339-3p, functioning through direct interaction with the 3' untranslated region of MCL1 mRNA. Blocking miR-339-3p by an antagomiR was sufficient to increase melanoma cell invasion, an effect that could be phenocopied by RNAi-mediated silencing of MCL1. In vivo studies established that miR-339-3p overexpression was sufficient to decrease lung colonization by A375 melanoma cells in NSG mice, relative to control cells. Overall, our results defined miR-339-3p as a melanoma tumor suppressor, the levels of which contributes to invasive aggressiveness. Cancer Res; 76(12); 3562-71. ©2016 AACR.
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000130828 650_7 $$2NLM Chemicals$$aMIRN-339 microRNA, mouse
000130828 650_7 $$2NLM Chemicals$$aMcl1 protein, mouse
000130828 650_7 $$2NLM Chemicals$$aMicroRNAs
000130828 650_7 $$2NLM Chemicals$$aMyeloid Cell Leukemia Sequence 1 Protein
000130828 7001_ $$0P:(DE-HGF)0$$aLuo, Chonglin$$b1
000130828 7001_ $$0P:(DE-He78)2f34b89d62d5e5c651aa1e683844b092$$aHotz-Wagenblatt, Agnes$$b2$$udkfz
000130828 7001_ $$0P:(DE-He78)cce6b51dcd85173b43b8b662ea47c700$$aGardyan, Adriane$$b3$$udkfz
000130828 7001_ $$0P:(DE-He78)70e630b77e8ddc41353fc23197569b7c$$aKordaß, Theresa$$b4$$udkfz
000130828 7001_ $$0P:(DE-He78)457c042884c901eb0a02c18bb1d30103$$aHolland-Letz, Tim$$b5$$udkfz
000130828 7001_ $$0P:(DE-He78)b757b21d60bbaa4164899bb7e61b0c15$$aOsen, Wolfram$$b6$$udkfz
000130828 7001_ $$0P:(DE-He78)23fb8cfffbf2aa8eee5d51af417ad944$$aEichmüller, Stefan$$b7$$eLast author$$udkfz
000130828 773__ $$0PERI:(DE-600)2036785-5$$a10.1158/0008-5472.CAN-15-2932$$gVol. 76, no. 12, p. 3562 - 3571$$n12$$p3562 - 3571$$tCancer research$$v76$$x1538-7445$$y2016
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