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@ARTICLE{Weber:130828,
      author       = {C. E. M. Weber$^*$ and C. Luo$^*$ and A.
                      Hotz-Wagenblatt$^*$ and A. Gardyan$^*$ and T. Kordaß$^*$
                      and T. Holland-Letz$^*$ and W. Osen$^*$ and S.
                      Eichmüller$^*$},
      title        = {mi{R}-339-3p {I}s a {T}umor {S}uppressor in {M}elanoma.},
      journal      = {Cancer research},
      volume       = {76},
      number       = {12},
      issn         = {1538-7445},
      address      = {Philadelphia, Pa.},
      publisher    = {AACR},
      reportid     = {DKFZ-2017-05906},
      pages        = {3562 - 3571},
      year         = {2016},
      abstract     = {Determinants of invasion and metastasis in cancer remain of
                      great interest to define. Here, we report the definition of
                      miR-339-3p as a novel tumor suppressive microRNA that blocks
                      melanoma cell invasion without affecting cell survival.
                      miR-339-3p was identified by a comprehensive functional
                      screen of a human miRNA mimetic library in a cell-based
                      assay for invasion by the melanoma cell line A375.
                      miR-339-3p was determined as a strong inhibitor of invasion
                      differentially expressed in melanoma cells and healthy
                      melanocytes. MCL1 was defined as a target for downregulation
                      by miR-339-3p, functioning through direct interaction with
                      the 3' untranslated region of MCL1 mRNA. Blocking miR-339-3p
                      by an antagomiR was sufficient to increase melanoma cell
                      invasion, an effect that could be phenocopied by
                      RNAi-mediated silencing of MCL1. In vivo studies established
                      that miR-339-3p overexpression was sufficient to decrease
                      lung colonization by A375 melanoma cells in NSG mice,
                      relative to control cells. Overall, our results defined
                      miR-339-3p as a melanoma tumor suppressor, the levels of
                      which contributes to invasive aggressiveness. Cancer Res;
                      76(12); 3562-71. ©2016 AACR.},
      keywords     = {MIRN-339 microRNA, mouse (NLM Chemicals) / Mcl1 protein,
                      mouse (NLM Chemicals) / MicroRNAs (NLM Chemicals) / Myeloid
                      Cell Leukemia Sequence 1 Protein (NLM Chemicals)},
      cin          = {G182 / W180 / C060},
      ddc          = {610},
      cid          = {I:(DE-He78)G182-20160331 / I:(DE-He78)W180-20160331 /
                      I:(DE-He78)C060-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:27197185},
      doi          = {10.1158/0008-5472.CAN-15-2932},
      url          = {https://inrepo02.dkfz.de/record/130828},
}