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| 001 | 130828 | ||
| 005 | 20240228143500.0 | ||
| 024 | 7 | _ | |a 10.1158/0008-5472.CAN-15-2932 |2 doi |
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| 100 | 1 | _ | |a Weber, Claudia E M |0 P:(DE-HGF)0 |b 0 |e First author |
| 245 | _ | _ | |a miR-339-3p Is a Tumor Suppressor in Melanoma. |
| 260 | _ | _ | |a Philadelphia, Pa. |c 2016 |b AACR |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 520 | _ | _ | |a Determinants of invasion and metastasis in cancer remain of great interest to define. Here, we report the definition of miR-339-3p as a novel tumor suppressive microRNA that blocks melanoma cell invasion without affecting cell survival. miR-339-3p was identified by a comprehensive functional screen of a human miRNA mimetic library in a cell-based assay for invasion by the melanoma cell line A375. miR-339-3p was determined as a strong inhibitor of invasion differentially expressed in melanoma cells and healthy melanocytes. MCL1 was defined as a target for downregulation by miR-339-3p, functioning through direct interaction with the 3' untranslated region of MCL1 mRNA. Blocking miR-339-3p by an antagomiR was sufficient to increase melanoma cell invasion, an effect that could be phenocopied by RNAi-mediated silencing of MCL1. In vivo studies established that miR-339-3p overexpression was sufficient to decrease lung colonization by A375 melanoma cells in NSG mice, relative to control cells. Overall, our results defined miR-339-3p as a melanoma tumor suppressor, the levels of which contributes to invasive aggressiveness. Cancer Res; 76(12); 3562-71. ©2016 AACR. |
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| 650 | _ | 7 | |a MicroRNAs |2 NLM Chemicals |
| 650 | _ | 7 | |a Myeloid Cell Leukemia Sequence 1 Protein |2 NLM Chemicals |
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| 700 | 1 | _ | |a Eichmüller, Stefan |0 P:(DE-He78)23fb8cfffbf2aa8eee5d51af417ad944 |b 7 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1158/0008-5472.CAN-15-2932 |g Vol. 76, no. 12, p. 3562 - 3571 |0 PERI:(DE-600)2036785-5 |n 12 |p 3562 - 3571 |t Cancer research |v 76 |y 2016 |x 1538-7445 |
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