TY  - JOUR
AU  - Kesch, Claudia
AU  - Vinsensia, Maria
AU  - Radtke, Jan Philipp
AU  - Schlemmer, Heinz-Peter
AU  - Heller, Martina
AU  - Ellert, Elena
AU  - Holland-Letz, Tim
AU  - Duensing, Stefan
AU  - Grabe, Nils
AU  - Afshar-Oromieh, Ali
AU  - Wieczorek, Kathrin
AU  - Schäfer, Martin
AU  - Neels, Oliver
AU  - Cardinale, Jens
AU  - Kratochwil, Clemens
AU  - Hohenfellner, Markus
AU  - Kopka, Klaus
AU  - Haberkorn, Uwe
AU  - Hadaschik, Boris A
AU  - Giesel, Frederik
TI  - Intraindividual Comparison of (18)F-PSMA-1007 PET/CT, Multiparametric MRI, and Radical Prostatectomy Specimens in Patients with Primary Prostate Cancer: A Retrospective, Proof-of-Concept Study.
JO  - Journal of nuclear medicine
VL  - 58
IS  - 11
SN  - 2159-662X
CY  - New York, NY
PB  - Soc.
M1  - DKFZ-2017-05908
SP  - 1805 - 1810
PY  - 2017
AB  - (68)Ga-prostate-specific membrane antigen (PSMA)-11 PET/CT represents an advanced method for the staging of primary prostate cancer (PCa) and diagnosis of recurrent or metastatic PCa. However, because of the narrow availability of (68)Ga the development of alternative tracers is of high interest. The objective of this study was to examine the value of the new PET tracer (18)F-PSMA-1007 for the staging of local disease by comparing it with multiparametric MRI (mpMRI) and radical prostatectomy (RP) histopathology. Methods: In 2016, (18)F-PSMA-1007 PET/CT was performed in 10 men with biopsy-confirmed high-risk PCa. Nine patients underwent mpMRI in the process of primary diagnosis. Consecutively, RP was performed in all 10 men. Agreement analysis was performed retrospectively. PSMA staining was added for representative sections in RP specimen slices. Localization and agreement analysis of (18)F-PSMA-1007 PET/CT, mpMRI, and RP specimens was performed by dividing the prostate into 38 sections as described in the prostate imaging reporting and data system (PI-RADS) (version 2). Sensitivity, specificity, positive predictive values, negative predictive values (NPVs), and accuracy were calculated for total and near-total agreement. Results:(18)F-PSMA-1007 PET/CT had an NPV of 68
LB  - PUB:(DE-HGF)16
C6  - pmid:28473595
DO  - DOI:10.2967/jnumed.116.189233
UR  - https://inrepo02.dkfz.de/record/130830
ER  -