Journal Article

DKFZ-2017-05908

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Intraindividual Comparison of (18)F-PSMA-1007 PET/CT, Multiparametric MRI, and Radical Prostatectomy Specimens in Patients with Primary Prostate Cancer: A Retrospective, Proof-of-Concept Study.

Kesch, C. ; Vinsensia, M. ; Radtke, J. P.DKFZ* ; Schlemmer, H.-P.DKFZ* ; Heller, M. ; Ellert, E. ; Holland-Letz, T.DKFZ* ; Duensing, S. ; Grabe, N. ; Afshar-Oromieh, A.DKFZ* ; Wieczorek, K. ; Schäfer, M.DKFZ* ; Neels, O.DKFZ* ; Cardinale, J.DKFZ* ; Kratochwil, C. ; Hohenfellner, M. ; Kopka, K.DKFZ* ; Haberkorn, U.DKFZ* ; Hadaschik, B. A. ; Giesel, F. (Last author)DKFZ*

2017
Soc. New York, NY

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Please use a persistent id in citations: doi:10.2967/jnumed.116.189233

Abstract: (68)Ga-prostate-specific membrane antigen (PSMA)-11 PET/CT represents an advanced method for the staging of primary prostate cancer (PCa) and diagnosis of recurrent or metastatic PCa. However, because of the narrow availability of (68)Ga the development of alternative tracers is of high interest. The objective of this study was to examine the value of the new PET tracer (18)F-PSMA-1007 for the staging of local disease by comparing it with multiparametric MRI (mpMRI) and radical prostatectomy (RP) histopathology. Methods: In 2016, (18)F-PSMA-1007 PET/CT was performed in 10 men with biopsy-confirmed high-risk PCa. Nine patients underwent mpMRI in the process of primary diagnosis. Consecutively, RP was performed in all 10 men. Agreement analysis was performed retrospectively. PSMA staining was added for representative sections in RP specimen slices. Localization and agreement analysis of (18)F-PSMA-1007 PET/CT, mpMRI, and RP specimens was performed by dividing the prostate into 38 sections as described in the prostate imaging reporting and data system (PI-RADS) (version 2). Sensitivity, specificity, positive predictive values, negative predictive values (NPVs), and accuracy were calculated for total and near-total agreement. Results:(18)F-PSMA-1007 PET/CT had an NPV of 68% and an accuracy of 75%, and mpMRI had an NPV of 88% and an accuracy of 73% for total agreement. Near-total agreement analysis resulted in an NPV of 91% and an accuracy of 93% for (18)F-PSMA-1007 PET/CT and 91% and 87% for mpMRI, respectively. Retrospective combination of mpMRI and PET/CT had an accuracy of 81% for total and 93% for near-total agreement. Conclusion: Comparison with RP histopathology demonstrates that (18)F-PSMA-1007 PET/CT is promising for accurate local staging of PCa.

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Contributing Institute(s):

1. Biostatistik (C060)
2. Radiologie (E010)
3. Radiopharmazeutische Chemie (E030)
4. KKE Nuklearmedizin (E060)
5. DKTK Heidelberg (L101)

Research Program(s):

1. 315 - Imaging and radiooncology (POF3-315) (POF3-315)

Appears in the scientific report 2017

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Database coverage:
; BIOSIS Previews ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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