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@ARTICLE{Kesch:130830,
      author       = {C. Kesch and M. Vinsensia and J. P. Radtke$^*$ and H.-P.
                      Schlemmer$^*$ and M. Heller and E. Ellert and T.
                      Holland-Letz$^*$ and S. Duensing and N. Grabe and A.
                      Afshar-Oromieh$^*$ and K. Wieczorek and M. Schäfer$^*$ and
                      O. Neels$^*$ and J. Cardinale$^*$ and C. Kratochwil and M.
                      Hohenfellner and K. Kopka$^*$ and U. Haberkorn$^*$ and B. A.
                      Hadaschik and F. Giesel$^*$},
      title        = {{I}ntraindividual {C}omparison of (18){F}-{PSMA}-1007
                      {PET}/{CT}, {M}ultiparametric {MRI}, and {R}adical
                      {P}rostatectomy {S}pecimens in {P}atients with {P}rimary
                      {P}rostate {C}ancer: {A} {R}etrospective,
                      {P}roof-of-{C}oncept {S}tudy.},
      journal      = {Journal of nuclear medicine},
      volume       = {58},
      number       = {11},
      issn         = {2159-662X},
      address      = {New York, NY},
      publisher    = {Soc.},
      reportid     = {DKFZ-2017-05908},
      pages        = {1805 - 1810},
      year         = {2017},
      abstract     = {(68)Ga-prostate-specific membrane antigen (PSMA)-11 PET/CT
                      represents an advanced method for the staging of primary
                      prostate cancer (PCa) and diagnosis of recurrent or
                      metastatic PCa. However, because of the narrow availability
                      of (68)Ga the development of alternative tracers is of high
                      interest. The objective of this study was to examine the
                      value of the new PET tracer (18)F-PSMA-1007 for the staging
                      of local disease by comparing it with multiparametric MRI
                      (mpMRI) and radical prostatectomy (RP) histopathology.
                      Methods: In 2016, (18)F-PSMA-1007 PET/CT was performed in 10
                      men with biopsy-confirmed high-risk PCa. Nine patients
                      underwent mpMRI in the process of primary diagnosis.
                      Consecutively, RP was performed in all 10 men. Agreement
                      analysis was performed retrospectively. PSMA staining was
                      added for representative sections in RP specimen slices.
                      Localization and agreement analysis of (18)F-PSMA-1007
                      PET/CT, mpMRI, and RP specimens was performed by dividing
                      the prostate into 38 sections as described in the prostate
                      imaging reporting and data system (PI-RADS) (version 2).
                      Sensitivity, specificity, positive predictive values,
                      negative predictive values (NPVs), and accuracy were
                      calculated for total and near-total agreement.
                      Results:(18)F-PSMA-1007 PET/CT had an NPV of $68\%$ and an
                      accuracy of $75\%,$ and mpMRI had an NPV of $88\%$ and an
                      accuracy of $73\%$ for total agreement. Near-total agreement
                      analysis resulted in an NPV of $91\%$ and an accuracy of
                      $93\%$ for (18)F-PSMA-1007 PET/CT and $91\%$ and $87\%$ for
                      mpMRI, respectively. Retrospective combination of mpMRI and
                      PET/CT had an accuracy of $81\%$ for total and $93\%$ for
                      near-total agreement. Conclusion: Comparison with RP
                      histopathology demonstrates that (18)F-PSMA-1007 PET/CT is
                      promising for accurate local staging of PCa.},
      cin          = {C060 / E010 / E030 / E060 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)C060-20160331 / I:(DE-He78)E010-20160331 /
                      I:(DE-He78)E030-20160331 / I:(DE-He78)E060-20160331 /
                      I:(DE-He78)L101-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28473595},
      doi          = {10.2967/jnumed.116.189233},
      url          = {https://inrepo02.dkfz.de/record/130830},
}