TY  - JOUR
AU  - Meehan, Terrence F
AU  - Conte, Nathalie
AU  - Goldstein, Theodore
AU  - Inghirami, Giorgio
AU  - Murakami, Mark A
AU  - Brabetz, Sebastian
AU  - Gu, Zhiping
AU  - Wiser, Jeffrey A
AU  - Dunn, Patrick
AU  - Begley, Dale A
AU  - Krupke, Debra M
AU  - Bertotti, Andrea
AU  - Bruna, Alejandra
AU  - Brush, Matthew H
AU  - Byrne, Annette T
AU  - Caldas, Carlos
AU  - Christie, Amanda L
AU  - Clark, Dominic A
AU  - Dowst, Heidi
AU  - Dry, Jonathan R
AU  - Doroshow, James H
AU  - Duchamp, Olivier
AU  - Evrard, Yvonne A
AU  - Ferretti, Stephane
AU  - Frese, Kristopher K
AU  - Goodwin, Neal C
AU  - Greenawalt, Danielle
AU  - Haendel, Melissa A
AU  - Hermans, Els
AU  - Houghton, Peter J
AU  - Jonkers, Jos
AU  - Kemper, Kristel
AU  - Khor, Tin O
AU  - Lewis, Michael T
AU  - Lloyd, K C Kent
AU  - Mason, Jeremy
AU  - Medico, Enzo
AU  - Neuhauser, Steven B
AU  - Olson, James M
AU  - Peeper, Daniel S
AU  - Rueda, Oscar M
AU  - Seong, Je Kyung
AU  - Trusolino, Livio
AU  - Vinolo, Emilie
AU  - Wechsler-Reya, Robert J
AU  - Weinstock, David M
AU  - Welm, Alana
AU  - Weroha, S John
AU  - Amant, Frédéric
AU  - Pfister, Stefan
AU  - Kool, Marcel
AU  - Parkinson, Helen
AU  - Butte, Atul J
AU  - Bult, Carol J
TI  - PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models.
JO  - Cancer research
VL  - 77
IS  - 21
SN  - 1538-7445
CY  - Philadelphia, Pa.
PB  - AACR
M1  - DKFZ-2017-05964
SP  - e62 - e66
PY  - 2017
AB  - Patient-derived tumor xenograft (PDX) mouse models have emerged as an important oncology research platform to study tumor evolution, mechanisms of drug response and resistance, and tailoring chemotherapeutic approaches for individual patients. The lack of robust standards for reporting on PDX models has hampered the ability of researchers to find relevant PDX models and associated data. Here we present the PDX models minimal information standard (PDX-MI) for reporting on the generation, quality assurance, and use of PDX models. PDX-MI defines the minimal information for describing the clinical attributes of a patient's tumor, the processes of implantation and passaging of tumors in a host mouse strain, quality assurance methods, and the use of PDX models in cancer research. Adherence to PDX-MI standards will facilitate accurate search results for oncology models and their associated data across distributed repository databases and promote reproducibility in research studies using these models. Cancer Res; 77(21); e62-66. ©2017 AACR.
LB  - PUB:(DE-HGF)16
C6  - pmid:29092942
DO  - DOI:10.1158/0008-5472.CAN-17-0582
UR  - https://inrepo02.dkfz.de/record/130888
ER  -