Journal Article

DKFZ-2017-05964

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models.

Meehan, T. F. ; Conte, N. ; Goldstein, T. ; Inghirami, G. ; Murakami, M. A. ; Brabetz, S.DKFZ* ; Gu, Z. ; Wiser, J. A. ; Dunn, P. ; Begley, D. A. ; Krupke, D. M. ; Bertotti, A. ; Bruna, A. ; Brush, M. H. ; Byrne, A. T. ; Caldas, C. ; Christie, A. L. ; Clark, D. A. ; Dowst, H. ; Dry, J. R. ; Doroshow, J. H. ; Duchamp, O. ; Evrard, Y. A. ; Ferretti, S. ; Frese, K. K. ; Goodwin, N. C. ; Greenawalt, D. ; Haendel, M. A. ; Hermans, E. ; Houghton, P. J. ; Jonkers, J. ; Kemper, K. ; Khor, T. O. ; Lewis, M. T. ; Lloyd, K. C. K. ; Mason, J. ; Medico, E. ; Neuhauser, S. B. ; Olson, J. M. ; Peeper, D. S. ; Rueda, O. M. ; Seong, J. K. ; Trusolino, L. ; Vinolo, E. ; Wechsler-Reya, R. J. ; Weinstock, D. M. ; Welm, A. ; Weroha, S. J. ; Amant, F. ; Pfister, S.DKFZ* ; Kool, M.DKFZ* ; Parkinson, H. ; Butte, A. J. ; Bult, C. J.

2017
AACR Philadelphia, Pa.

This record in other databases:  

Please use a persistent id in citations: doi:10.1158/0008-5472.CAN-17-0582

Abstract: Patient-derived tumor xenograft (PDX) mouse models have emerged as an important oncology research platform to study tumor evolution, mechanisms of drug response and resistance, and tailoring chemotherapeutic approaches for individual patients. The lack of robust standards for reporting on PDX models has hampered the ability of researchers to find relevant PDX models and associated data. Here we present the PDX models minimal information standard (PDX-MI) for reporting on the generation, quality assurance, and use of PDX models. PDX-MI defines the minimal information for describing the clinical attributes of a patient's tumor, the processes of implantation and passaging of tumors in a host mouse strain, quality assurance methods, and the use of PDX models in cancer research. Adherence to PDX-MI standards will facilitate accurate search results for oncology models and their associated data across distributed repository databases and promote reproducibility in research studies using these models. Cancer Res; 77(21); e62-66. ©2017 AACR.

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Contributing Institute(s):

1. B062 Pädiatrische Neuroonkologie (B062)
2. DKTK Heidelberg (L101)

Research Program(s):

1. 312 - Functional and structural genomics (POF3-312) (POF3-312)

Appears in the scientific report 2017

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Database coverage:
; BIOSIS Previews ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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