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000130910 0247_ $$2ISSN$$a1545-5009
000130910 0247_ $$2ISSN$$a1545-5017
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000130910 037__ $$aDKFZ-2017-05986
000130910 041__ $$aeng
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000130910 1001_ $$aSenfter, Daniel$$b0
000130910 245__ $$aOverexpression of minichromosome maintenance protein 10 in medulloblastoma and its clinical implications.
000130910 260__ $$aNew York, NY$$bWiley$$c2017
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000130910 520__ $$aOverexpression of minichromosome maintenance (MCM) proteins 2, 3, and 7 is associated with migration and invasion in medulloblastoma (MB). However, expression profiling of all prereplication complex (pre-RC) has not been addressed in MBs.We performed mRNA expression profiling of a large set of pre-RC elements in cell lines and tumor tissues of MB. RNAi technology was employed for functional studies in MB cell lines.Our data showed that most of the pre-RC components are significantly overexpressed in MB. Among all pre-RC mRNAs, MCM10 showed the highest level of expression (∼500- to 1,000-fold) in MB cell lines and tissues compared to the levels detected in cerebellum. In addition, RNAi silencing of MCM10 caused reduced cell proliferation and cell viability in MB cells.Taken together, our study reveals that the pre-RC is dysregulated in MB. In addition, MCM10, a member of this complex, is significantly overexpressed in MB and is required for tumor cell proliferation.
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000130910 650_7 $$2NLM Chemicals$$aMCM10 protein, human
000130910 650_7 $$0EC 3.6.4.12$$2NLM Chemicals$$aMinichromosome Maintenance Proteins
000130910 7001_ $$aErkan, Erdogan Pekcan$$b1
000130910 7001_ $$aÖzer, Erdener$$b2
000130910 7001_ $$aJungwirth, Gerhard$$b3
000130910 7001_ $$aMadlener, Sibylle$$b4
000130910 7001_ $$0P:(DE-He78)4c28e2aade5f44d8eca9dd8e97638ec8$$aKool, Marcel$$b5$$udkfz
000130910 7001_ $$aStröbel, Thomas$$b6
000130910 7001_ $$00000-0002-0511-7721$$aSaydam, Nurten$$b7
000130910 7001_ $$aSaydam, Okay$$b8
000130910 773__ $$0PERI:(DE-600)2130978-4$$a10.1002/pbc.26670$$gVol. 64, no. 12, p. e26670 -$$n12$$pe26670 -$$tPediatric blood & cancer$$v64$$x1545-5009$$y2017
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000130910 9141_ $$y2017
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