guest ::
| Home > Publications database > Overexpression of minichromosome maintenance protein 10 in medulloblastoma and its clinical implications. > print |
| Home > Publications database > Overexpression of minichromosome maintenance protein 10 in medulloblastoma and its clinical implications. > print |
| 001 | 130910 | ||
| 005 | 20240228145558.0 | ||
| 024 | 7 | _ | |a 10.1002/pbc.26670 |2 doi |
| 024 | 7 | _ | |a pmid:28598542 |2 pmid |
| 024 | 7 | _ | |a 0098-1532 |2 ISSN |
| 024 | 7 | _ | |a 1096-911X |2 ISSN |
| 024 | 7 | _ | |a 1545-5009 |2 ISSN |
| 024 | 7 | _ | |a 1545-5017 |2 ISSN |
| 024 | 7 | _ | |a altmetric:20929840 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2017-05986 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Senfter, Daniel |b 0 |
| 245 | _ | _ | |a Overexpression of minichromosome maintenance protein 10 in medulloblastoma and its clinical implications. |
| 260 | _ | _ | |a New York, NY |c 2017 |b Wiley |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1525777704_9525 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Overexpression of minichromosome maintenance (MCM) proteins 2, 3, and 7 is associated with migration and invasion in medulloblastoma (MB). However, expression profiling of all prereplication complex (pre-RC) has not been addressed in MBs.We performed mRNA expression profiling of a large set of pre-RC elements in cell lines and tumor tissues of MB. RNAi technology was employed for functional studies in MB cell lines.Our data showed that most of the pre-RC components are significantly overexpressed in MB. Among all pre-RC mRNAs, MCM10 showed the highest level of expression (∼500- to 1,000-fold) in MB cell lines and tissues compared to the levels detected in cerebellum. In addition, RNAi silencing of MCM10 caused reduced cell proliferation and cell viability in MB cells.Taken together, our study reveals that the pre-RC is dysregulated in MB. In addition, MCM10, a member of this complex, is significantly overexpressed in MB and is required for tumor cell proliferation. |
| 536 | _ | _ | |a 312 - Functional and structural genomics (POF3-312) |0 G:(DE-HGF)POF3-312 |c POF3-312 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a MCM10 protein, human |2 NLM Chemicals |
| 650 | _ | 7 | |a Minichromosome Maintenance Proteins |0 EC 3.6.4.12 |2 NLM Chemicals |
| 700 | 1 | _ | |a Erkan, Erdogan Pekcan |b 1 |
| 700 | 1 | _ | |a Özer, Erdener |b 2 |
| 700 | 1 | _ | |a Jungwirth, Gerhard |b 3 |
| 700 | 1 | _ | |a Madlener, Sibylle |b 4 |
| 700 | 1 | _ | |a Kool, Marcel |0 P:(DE-He78)4c28e2aade5f44d8eca9dd8e97638ec8 |b 5 |u dkfz |
| 700 | 1 | _ | |a Ströbel, Thomas |b 6 |
| 700 | 1 | _ | |a Saydam, Nurten |0 0000-0002-0511-7721 |b 7 |
| 700 | 1 | _ | |a Saydam, Okay |b 8 |
| 773 | _ | _ | |a 10.1002/pbc.26670 |g Vol. 64, no. 12, p. e26670 - |0 PERI:(DE-600)2130978-4 |n 12 |p e26670 - |t Pediatric blood & cancer |v 64 |y 2017 |x 1545-5009 |
| 909 | C | O | |o oai:inrepo02.dkfz.de:130910 |p VDB |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 5 |6 P:(DE-He78)4c28e2aade5f44d8eca9dd8e97638ec8 |
| 913 | 1 | _ | |a DE-HGF |l Krebsforschung |1 G:(DE-HGF)POF3-310 |0 G:(DE-HGF)POF3-312 |2 G:(DE-HGF)POF3-300 |v Functional and structural genomics |x 0 |4 G:(DE-HGF)POF |3 G:(DE-HGF)POF3 |b Gesundheit |
| 914 | 1 | _ | |y 2017 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0310 |2 StatID |b NCBI Molecular Biology Database |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b PEDIATR BLOOD CANCER : 2015 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Thomson Reuters Master Journal List |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0110 |2 StatID |b Science Citation Index |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0111 |2 StatID |b Science Citation Index Expanded |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1110 |2 StatID |b Current Contents - Clinical Medicine |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |
| 915 | _ | _ | |a IF < 5 |0 StatID:(DE-HGF)9900 |2 StatID |
| 920 | 1 | _ | |0 I:(DE-He78)B062-20160331 |k B062 |l Pädiatrische Neuroonkologie |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-He78)B062-20160331 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|