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000131816 1001_ $$00000-0001-8367-2352$$avan Duijnhoven, Fränzel J B$$b0
000131816 245__ $$aCirculating concentrations of vitamin D in relation to pancreatic cancer risk in European populations.
000131816 260__ $$aBognor Regis$$bWiley-Liss$$c2018
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000131816 520__ $$aEvidence from in vivo, in vitro and ecological studies are suggestive of a protective effect of vitamin D against pancreatic cancer (PC). However, this has not been confirmed by analytical epidemiological studies. We aimed to examine the association between pre-diagnostic circulating vitamin D concentrations and PC incidence in European populations. We conducted a pooled nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Nord-Trøndelag Health Study's second survey (HUNT2) cohorts. In total, 738 primary incident PC cases (EPIC n = 626; HUNT2 n = 112; median follow-up = 6.9 years) were matched to 738 controls. Vitamin D [25(OH)D2 and 25(OH)D3 combined] concentrations were determined using isotope-dilution liquid chromatography-tandem mass spectrometry. Conditional logistic regression models with adjustments for body mass index and smoking habits were used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (95%CI). Compared with a reference category of >50 to 75 nmol/L vitamin D, the IRRs (95% CIs) were 0.71 (0.42-1.20); 0.94 (0.72-1.22); 1.12 (0.82-1.53) and 1.26 (0.79-2.01) for clinically pre-defined categories of ≤25; >25 to 50; >75 to 100; and >100 nmol/L vitamin D, respectively (p for trend = 0.09). Corresponding analyses by quintiles of season-standardized vitamin D concentrations also did not reveal associations with PC risk (p for trend = 0.23). Although these findings among participants from the largest combination of European cohort studies to date show increasing effect estimates of PC risk with increasing pre-diagnostic concentrations of vitamin D, they are not statistically significant.
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000131816 7001_ $$aJenab, Mazda$$b1
000131816 7001_ $$aHveem, Kristian$$b2
000131816 7001_ $$aSiersema, Peter D$$b3
000131816 7001_ $$aFedirko, Veronika$$b4
000131816 7001_ $$00000-0001-5256-0163$$aDuell, Eric J$$b5
000131816 7001_ $$aKampman, Ellen$$b6
000131816 7001_ $$aHalfweeg, Anouk$$b7
000131816 7001_ $$avan Kranen, Henk J$$b8
000131816 7001_ $$avan den Ouweland, Jody M W$$b9
000131816 7001_ $$aWeiderpass, Elisabete$$b10
000131816 7001_ $$aMurphy, Neil$$b11
000131816 7001_ $$aLanghammer, Arnulf$$b12
000131816 7001_ $$aNess-Jensen, Eivind$$b13
000131816 7001_ $$aOlsen, Anja$$b14
000131816 7001_ $$aTjønneland, Anne$$b15
000131816 7001_ $$aOvervad, Kim$$b16
000131816 7001_ $$aCadeau, Claire$$b17
000131816 7001_ $$aKvaskoff, Marina$$b18
000131816 7001_ $$aBoutron-Ruault, Marie-Christine$$b19
000131816 7001_ $$0P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4$$aKatzke, Verena$$b20$$udkfz
000131816 7001_ $$00000-0001-7702-317X$$aKühn, Tilman$$b21
000131816 7001_ $$aBoeing, Heiner$$b22
000131816 7001_ $$aTrichopoulou, Antonia$$b23
000131816 7001_ $$aKotanidou, Anastasia$$b24
000131816 7001_ $$aKritikou, Maria$$b25
000131816 7001_ $$00000-0002-5558-2437$$aPalli, Domenico$$b26
000131816 7001_ $$aAgnoli, Claudia$$b27
000131816 7001_ $$aTumino, Rosario$$b28
000131816 7001_ $$aPanico, Salvatore$$b29
000131816 7001_ $$aMatullo, Giuseppe$$b30
000131816 7001_ $$aPeeters, Petra$$b31
000131816 7001_ $$aBrustad, Magritt$$b32
000131816 7001_ $$aOlsen, Karina Standahl$$b33
000131816 7001_ $$aLasheras, Cristina$$b34
000131816 7001_ $$aObón-Santacana, Mireia$$b35
000131816 7001_ $$aSánchez, María-José$$b36
000131816 7001_ $$aDorronsoro, Miren$$b37
000131816 7001_ $$aChirlaque, Maria-Dolores$$b38
000131816 7001_ $$aBarricarte, Aurelio$$b39
000131816 7001_ $$aManjer, Jonas$$b40
000131816 7001_ $$aAlmquist, Martin$$b41
000131816 7001_ $$aRenström, Frida$$b42
000131816 7001_ $$00000-0002-6859-4648$$aYe, Weimin$$b43
000131816 7001_ $$aWareham, Nick$$b44
000131816 7001_ $$aKhaw, Kay-Tee$$b45
000131816 7001_ $$00000-0003-3345-7333$$aBradbury, Kathryn E$$b46
000131816 7001_ $$aFreisling, Heinz$$b47
000131816 7001_ $$aAune, Dagfinn$$b48
000131816 7001_ $$aNorat, Teresa$$b49
000131816 7001_ $$aRiboli, Elio$$b50
000131816 7001_ $$aBueno-de-Mesquita, H B As$$b51
000131816 773__ $$0PERI:(DE-600)1474822-8$$a10.1002/ijc.31146$$gVol. 142, no. 6, p. 1189 - 1201$$n6$$p1189 - 1201$$tInternational journal of cancer$$v142$$x0020-7136$$y2018
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