Journal Article

DKFZ-2018-00111

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations.

van Duijnhoven, F. J. B. ; Jenab, M. ; Hveem, K. ; Siersema, P. D. ; Fedirko, V. ; Duell, E. J. ; Kampman, E. ; Halfweeg, A. ; van Kranen, H. J. ; van den Ouweland, J. M. W. ; Weiderpass, E. ; Murphy, N. ; Langhammer, A. ; Ness-Jensen, E. ; Olsen, A. ; Tjønneland, A. ; Overvad, K. ; Cadeau, C. ; Kvaskoff, M. ; Boutron-Ruault, M.-C. ; Katzke, V.DKFZ* ; Kühn, T.DKFZ* ; Boeing, H. ; Trichopoulou, A. ; Kotanidou, A. ; Kritikou, M. ; Palli, D. ; Agnoli, C. ; Tumino, R. ; Panico, S. ; Matullo, G. ; Peeters, P. ; Brustad, M. ; Olsen, K. S. ; Lasheras, C. ; Obón-Santacana, M. ; Sánchez, M.-J. ; Dorronsoro, M. ; Chirlaque, M.-D. ; Barricarte, A. ; Manjer, J. ; Almquist, M. ; Renström, F. ; Ye, W. ; Wareham, N. ; Khaw, K.-T. ; Bradbury, K. E. ; Freisling, H. ; Aune, D. ; Norat, T. ; Riboli, E. ; Bueno-de-Mesquita, H. B. A.

2018
Wiley-Liss Bognor Regis

This record in other databases:  

Please use a persistent id in citations: doi:10.1002/ijc.31146

Abstract: Evidence from in vivo, in vitro and ecological studies are suggestive of a protective effect of vitamin D against pancreatic cancer (PC). However, this has not been confirmed by analytical epidemiological studies. We aimed to examine the association between pre-diagnostic circulating vitamin D concentrations and PC incidence in European populations. We conducted a pooled nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Nord-Trøndelag Health Study's second survey (HUNT2) cohorts. In total, 738 primary incident PC cases (EPIC n = 626; HUNT2 n = 112; median follow-up = 6.9 years) were matched to 738 controls. Vitamin D [25(OH)D2 and 25(OH)D3 combined] concentrations were determined using isotope-dilution liquid chromatography-tandem mass spectrometry. Conditional logistic regression models with adjustments for body mass index and smoking habits were used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (95%CI). Compared with a reference category of >50 to 75 nmol/L vitamin D, the IRRs (95% CIs) were 0.71 (0.42-1.20); 0.94 (0.72-1.22); 1.12 (0.82-1.53) and 1.26 (0.79-2.01) for clinically pre-defined categories of ≤25; >25 to 50; >75 to 100; and >100 nmol/L vitamin D, respectively (p for trend = 0.09). Corresponding analyses by quintiles of season-standardized vitamin D concentrations also did not reveal associations with PC risk (p for trend = 0.23). Although these findings among participants from the largest combination of European cohort studies to date show increasing effect estimates of PC risk with increasing pre-diagnostic concentrations of vitamin D, they are not statistically significant.

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Contributing Institute(s):

1. Epidemiologie von Krebserkrankungen (C020)

Research Program(s):

1. 313 - Cancer risk factors and prevention (POF3-313) (POF3-313)

Appears in the scientific report 2018

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Database coverage:
; BIOSIS Previews ; Current Contents - Life Sciences ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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