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@ARTICLE{vanDuijnhoven:131816,
      author       = {F. J. B. van Duijnhoven and M. Jenab and K. Hveem and P. D.
                      Siersema and V. Fedirko and E. J. Duell and E. Kampman and
                      A. Halfweeg and H. J. van Kranen and J. M. W. van den
                      Ouweland and E. Weiderpass and N. Murphy and A. Langhammer
                      and E. Ness-Jensen and A. Olsen and A. Tjønneland and K.
                      Overvad and C. Cadeau and M. Kvaskoff and M.-C.
                      Boutron-Ruault and V. Katzke$^*$ and T. Kühn$^*$ and H.
                      Boeing and A. Trichopoulou and A. Kotanidou and M. Kritikou
                      and D. Palli and C. Agnoli and R. Tumino and S. Panico and
                      G. Matullo and P. Peeters and M. Brustad and K. S. Olsen and
                      C. Lasheras and M. Obón-Santacana and M.-J. Sánchez and M.
                      Dorronsoro and M.-D. Chirlaque and A. Barricarte and J.
                      Manjer and M. Almquist and F. Renström and W. Ye and N.
                      Wareham and K.-T. Khaw and K. E. Bradbury and H. Freisling
                      and D. Aune and T. Norat and E. Riboli and H. B. A.
                      Bueno-de-Mesquita},
      title        = {{C}irculating concentrations of vitamin {D} in relation to
                      pancreatic cancer risk in {E}uropean populations.},
      journal      = {International journal of cancer},
      volume       = {142},
      number       = {6},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2018-00111},
      pages        = {1189 - 1201},
      year         = {2018},
      abstract     = {Evidence from in vivo, in vitro and ecological studies are
                      suggestive of a protective effect of vitamin D against
                      pancreatic cancer (PC). However, this has not been confirmed
                      by analytical epidemiological studies. We aimed to examine
                      the association between pre-diagnostic circulating vitamin D
                      concentrations and PC incidence in European populations. We
                      conducted a pooled nested case-control study within the
                      European Prospective Investigation into Cancer and Nutrition
                      (EPIC) and the Nord-Trøndelag Health Study's second survey
                      (HUNT2) cohorts. In total, 738 primary incident PC cases
                      (EPIC n = 626; HUNT2 n = 112; median
                      follow-up = 6.9 years) were matched to 738 controls.
                      Vitamin D [25(OH)D2 and 25(OH)D3 combined] concentrations
                      were determined using isotope-dilution liquid
                      chromatography-tandem mass spectrometry. Conditional
                      logistic regression models with adjustments for body mass
                      index and smoking habits were used to estimate incidence
                      rate ratios (IRRs) and $95\%$ confidence intervals
                      $(95\%CI).$ Compared with a reference category of >50 to 75
                      nmol/L vitamin D, the IRRs $(95\%$ CIs) were 0.71
                      (0.42-1.20); 0.94 (0.72-1.22); 1.12 (0.82-1.53) and 1.26
                      (0.79-2.01) for clinically pre-defined categories of ≤25;
                      >25 to 50; >75 to 100; and >100 nmol/L vitamin D,
                      respectively (p for trend = 0.09). Corresponding
                      analyses by quintiles of season-standardized vitamin D
                      concentrations also did not reveal associations with PC risk
                      (p for trend = 0.23). Although these findings among
                      participants from the largest combination of European cohort
                      studies to date show increasing effect estimates of PC risk
                      with increasing pre-diagnostic concentrations of vitamin D,
                      they are not statistically significant.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29114875},
      doi          = {10.1002/ijc.31146},
      url          = {https://inrepo02.dkfz.de/record/131816},
}