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| 001 | 131816 | ||
| 005 | 20240229105015.0 | ||
| 024 | 7 | _ | |a 10.1002/ijc.31146 |2 doi |
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| 024 | 7 | _ | |a 0020-7136 |2 ISSN |
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| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a van Duijnhoven, Fränzel J B |0 0000-0001-8367-2352 |b 0 |
| 245 | _ | _ | |a Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations. |
| 260 | _ | _ | |a Bognor Regis |c 2018 |b Wiley-Liss |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1521453513_12159 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Evidence from in vivo, in vitro and ecological studies are suggestive of a protective effect of vitamin D against pancreatic cancer (PC). However, this has not been confirmed by analytical epidemiological studies. We aimed to examine the association between pre-diagnostic circulating vitamin D concentrations and PC incidence in European populations. We conducted a pooled nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Nord-Trøndelag Health Study's second survey (HUNT2) cohorts. In total, 738 primary incident PC cases (EPIC n = 626; HUNT2 n = 112; median follow-up = 6.9 years) were matched to 738 controls. Vitamin D [25(OH)D2 and 25(OH)D3 combined] concentrations were determined using isotope-dilution liquid chromatography-tandem mass spectrometry. Conditional logistic regression models with adjustments for body mass index and smoking habits were used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (95%CI). Compared with a reference category of >50 to 75 nmol/L vitamin D, the IRRs (95% CIs) were 0.71 (0.42-1.20); 0.94 (0.72-1.22); 1.12 (0.82-1.53) and 1.26 (0.79-2.01) for clinically pre-defined categories of ≤25; >25 to 50; >75 to 100; and >100 nmol/L vitamin D, respectively (p for trend = 0.09). Corresponding analyses by quintiles of season-standardized vitamin D concentrations also did not reveal associations with PC risk (p for trend = 0.23). Although these findings among participants from the largest combination of European cohort studies to date show increasing effect estimates of PC risk with increasing pre-diagnostic concentrations of vitamin D, they are not statistically significant. |
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| 700 | 1 | _ | |a Jenab, Mazda |b 1 |
| 700 | 1 | _ | |a Hveem, Kristian |b 2 |
| 700 | 1 | _ | |a Siersema, Peter D |b 3 |
| 700 | 1 | _ | |a Fedirko, Veronika |b 4 |
| 700 | 1 | _ | |a Duell, Eric J |0 0000-0001-5256-0163 |b 5 |
| 700 | 1 | _ | |a Kampman, Ellen |b 6 |
| 700 | 1 | _ | |a Halfweeg, Anouk |b 7 |
| 700 | 1 | _ | |a van Kranen, Henk J |b 8 |
| 700 | 1 | _ | |a van den Ouweland, Jody M W |b 9 |
| 700 | 1 | _ | |a Weiderpass, Elisabete |b 10 |
| 700 | 1 | _ | |a Murphy, Neil |b 11 |
| 700 | 1 | _ | |a Langhammer, Arnulf |b 12 |
| 700 | 1 | _ | |a Ness-Jensen, Eivind |b 13 |
| 700 | 1 | _ | |a Olsen, Anja |b 14 |
| 700 | 1 | _ | |a Tjønneland, Anne |b 15 |
| 700 | 1 | _ | |a Overvad, Kim |b 16 |
| 700 | 1 | _ | |a Cadeau, Claire |b 17 |
| 700 | 1 | _ | |a Kvaskoff, Marina |b 18 |
| 700 | 1 | _ | |a Boutron-Ruault, Marie-Christine |b 19 |
| 700 | 1 | _ | |a Katzke, Verena |0 P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4 |b 20 |u dkfz |
| 700 | 1 | _ | |a Kühn, Tilman |0 0000-0001-7702-317X |b 21 |
| 700 | 1 | _ | |a Boeing, Heiner |b 22 |
| 700 | 1 | _ | |a Trichopoulou, Antonia |b 23 |
| 700 | 1 | _ | |a Kotanidou, Anastasia |b 24 |
| 700 | 1 | _ | |a Kritikou, Maria |b 25 |
| 700 | 1 | _ | |a Palli, Domenico |0 0000-0002-5558-2437 |b 26 |
| 700 | 1 | _ | |a Agnoli, Claudia |b 27 |
| 700 | 1 | _ | |a Tumino, Rosario |b 28 |
| 700 | 1 | _ | |a Panico, Salvatore |b 29 |
| 700 | 1 | _ | |a Matullo, Giuseppe |b 30 |
| 700 | 1 | _ | |a Peeters, Petra |b 31 |
| 700 | 1 | _ | |a Brustad, Magritt |b 32 |
| 700 | 1 | _ | |a Olsen, Karina Standahl |b 33 |
| 700 | 1 | _ | |a Lasheras, Cristina |b 34 |
| 700 | 1 | _ | |a Obón-Santacana, Mireia |b 35 |
| 700 | 1 | _ | |a Sánchez, María-José |b 36 |
| 700 | 1 | _ | |a Dorronsoro, Miren |b 37 |
| 700 | 1 | _ | |a Chirlaque, Maria-Dolores |b 38 |
| 700 | 1 | _ | |a Barricarte, Aurelio |b 39 |
| 700 | 1 | _ | |a Manjer, Jonas |b 40 |
| 700 | 1 | _ | |a Almquist, Martin |b 41 |
| 700 | 1 | _ | |a Renström, Frida |b 42 |
| 700 | 1 | _ | |a Ye, Weimin |0 0000-0002-6859-4648 |b 43 |
| 700 | 1 | _ | |a Wareham, Nick |b 44 |
| 700 | 1 | _ | |a Khaw, Kay-Tee |b 45 |
| 700 | 1 | _ | |a Bradbury, Kathryn E |0 0000-0003-3345-7333 |b 46 |
| 700 | 1 | _ | |a Freisling, Heinz |b 47 |
| 700 | 1 | _ | |a Aune, Dagfinn |b 48 |
| 700 | 1 | _ | |a Norat, Teresa |b 49 |
| 700 | 1 | _ | |a Riboli, Elio |b 50 |
| 700 | 1 | _ | |a Bueno-de-Mesquita, H B As |b 51 |
| 773 | _ | _ | |a 10.1002/ijc.31146 |g Vol. 142, no. 6, p. 1189 - 1201 |0 PERI:(DE-600)1474822-8 |n 6 |p 1189 - 1201 |t International journal of cancer |v 142 |y 2018 |x 0020-7136 |
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