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000132559 245__ $$amiR-137 inhibits melanoma cell proliferation through downregulation of GLO1.
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000132559 500__ $$a2018 May;61(5):541-549
000132559 520__ $$aLate-stage melanoma is refractory to current therapies. MicroRNAs (miRNAs) can modulate many physiological and pathological processes of melanoma. Studies have demonstrated that miR-137 acts as a tumor suppressor by inhibiting the proliferation of melanoma cells through targeting multiple mRNAs. The glyoxalase system member glyoxalase 1 (GLO1) is the principal scavenging enzyme of methylglyoxal (MG), a toxic byproduct of glycolysis. Using35S in vivo/vitro labelling analysis for dynamic proteomics (SiLAD), we found that miR-137 downregulated the expression of GLO1 in melanoma cells. Bioinformatics analysis predicted that GLO1 is a direct target of miR-137. This was validated by dual luciferase reporter assay. Quantitative RT-PCR (qRT-PCR) and western blot analysis indicated that miR-137 could decrease endogenous GLO1 expression. Furthermore, siRNA targeting of GLO1 mimicked inhibition of melanoma cell proliferation caused by miR-137 overexpression. Re-expression of GLO1 was able to restore miR-137-mediated suppression of melanoma cell proliferation. Therefore, these results suggest that miR-137 inhibits the proliferation of melanoma cells by targeting GLO1.
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000132559 7001_ $$aHao, Shuai$$b1
000132559 7001_ $$aLuo, Chonglin$$b2
000132559 7001_ $$0P:(DE-He78)ee782484657011f0081a1425afa47a3f$$aAbukiwan, Alia$$b3$$udkfz
000132559 7001_ $$aHao, Ying$$b4
000132559 7001_ $$aGai, Fei$$b5
000132559 7001_ $$aHuang, Weiwei$$b6
000132559 7001_ $$aHuang, Lingyun$$b7
000132559 7001_ $$aXiao, Xueyuan$$b8
000132559 7001_ $$0P:(DE-He78)23fb8cfffbf2aa8eee5d51af417ad944$$aEichmüller, Stefan$$b9$$udkfz
000132559 7001_ $$aHe, Dacheng$$b10
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