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@ARTICLE{Lv:132559,
      author       = {N. Lv and S. Hao and C. Luo and A. Abukiwan$^*$ and Y. Hao
                      and F. Gai and W. Huang and L. Huang and X. Xiao and S.
                      Eichmüller$^*$ and D. He},
      title        = {mi{R}-137 inhibits melanoma cell proliferation through
                      downregulation of {GLO}1.},
      journal      = {Science in China / C},
      volume       = {61},
      number       = {5},
      issn         = {1869-1889},
      address      = {Heidelberg},
      publisher    = {Springer37831},
      reportid     = {DKFZ-2018-00237},
      pages        = {541-549},
      year         = {2018},
      note         = {2018 May;61(5):541-549},
      abstract     = {Late-stage melanoma is refractory to current therapies.
                      MicroRNAs (miRNAs) can modulate many physiological and
                      pathological processes of melanoma. Studies have
                      demonstrated that miR-137 acts as a tumor suppressor by
                      inhibiting the proliferation of melanoma cells through
                      targeting multiple mRNAs. The glyoxalase system member
                      glyoxalase 1 (GLO1) is the principal scavenging enzyme of
                      methylglyoxal (MG), a toxic byproduct of glycolysis.
                      Using35S in vivo/vitro labelling analysis for dynamic
                      proteomics (SiLAD), we found that miR-137 downregulated the
                      expression of GLO1 in melanoma cells. Bioinformatics
                      analysis predicted that GLO1 is a direct target of miR-137.
                      This was validated by dual luciferase reporter assay.
                      Quantitative RT-PCR (qRT-PCR) and western blot analysis
                      indicated that miR-137 could decrease endogenous GLO1
                      expression. Furthermore, siRNA targeting of GLO1 mimicked
                      inhibition of melanoma cell proliferation caused by miR-137
                      overexpression. Re-expression of GLO1 was able to restore
                      miR-137-mediated suppression of melanoma cell proliferation.
                      Therefore, these results suggest that miR-137 inhibits the
                      proliferation of melanoma cells by targeting GLO1.},
      cin          = {G182},
      ddc          = {570},
      cid          = {I:(DE-He78)G182-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29307109},
      doi          = {10.1007/s11427-017-9138-9},
      url          = {https://inrepo02.dkfz.de/record/132559},
}