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| 245 | _ | _ | |a miR-137 inhibits melanoma cell proliferation through downregulation of GLO1. |
| 260 | _ | _ | |a Heidelberg |c 2018 |b Springer37831 |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 500 | _ | _ | |a 2018 May;61(5):541-549 |
| 520 | _ | _ | |a Late-stage melanoma is refractory to current therapies. MicroRNAs (miRNAs) can modulate many physiological and pathological processes of melanoma. Studies have demonstrated that miR-137 acts as a tumor suppressor by inhibiting the proliferation of melanoma cells through targeting multiple mRNAs. The glyoxalase system member glyoxalase 1 (GLO1) is the principal scavenging enzyme of methylglyoxal (MG), a toxic byproduct of glycolysis. Using35S in vivo/vitro labelling analysis for dynamic proteomics (SiLAD), we found that miR-137 downregulated the expression of GLO1 in melanoma cells. Bioinformatics analysis predicted that GLO1 is a direct target of miR-137. This was validated by dual luciferase reporter assay. Quantitative RT-PCR (qRT-PCR) and western blot analysis indicated that miR-137 could decrease endogenous GLO1 expression. Furthermore, siRNA targeting of GLO1 mimicked inhibition of melanoma cell proliferation caused by miR-137 overexpression. Re-expression of GLO1 was able to restore miR-137-mediated suppression of melanoma cell proliferation. Therefore, these results suggest that miR-137 inhibits the proliferation of melanoma cells by targeting GLO1. |
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| 700 | 1 | _ | |a Gai, Fei |b 5 |
| 700 | 1 | _ | |a Huang, Weiwei |b 6 |
| 700 | 1 | _ | |a Huang, Lingyun |b 7 |
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| 773 | _ | _ | |a 10.1007/s11427-017-9138-9 |0 PERI:(DE-600)2133225-3 |n 5 |p 541-549 |t Science in China / C |v 61 |y 2018 |x 1869-1889 |
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