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@ARTICLE{Matt:132584,
      author       = {S. Matt$^*$ and T. Hofmann$^*$},
      title        = {{T}he {DNA} damage-induced cell death response: a roadmap
                      to kill cancer cells.},
      journal      = {Cellular and molecular life sciences},
      volume       = {73},
      number       = {15},
      issn         = {1420-9071},
      address      = {Basel},
      publisher    = {Birkhäuser},
      reportid     = {DKFZ-2018-00250},
      pages        = {2829 - 2850},
      year         = {2016},
      note         = {review, ZMBH Allianz},
      abstract     = {Upon massive DNA damage cells fail to undergo productive
                      DNA repair and trigger the cell death response. Resistance
                      to cell death is linked to cellular transformation and
                      carcinogenesis as well as radio- and chemoresistance, making
                      the underlying signaling pathways a promising target for
                      therapeutic intervention. Diverse DNA damage-induced cell
                      death pathways are operative in mammalian cells and finally
                      culminate in the induction of programmed cell death via
                      activation of apoptosis or necroptosis. These signaling
                      routes affect nuclear, mitochondria- and plasma
                      membrane-associated key molecules to activate the apoptotic
                      or necroptotic response. In this review, we highlight the
                      main signaling pathways, molecular players and mechanisms
                      guiding the DNA damage-induced cell death response.},
      cin          = {A210 / A130},
      ddc          = {570},
      cid          = {I:(DE-He78)A210-20160331 / I:(DE-He78)A130-20160331},
      pnm          = {311 - Signalling pathways, cell and tumor biology
                      (POF3-311)},
      pid          = {G:(DE-HGF)POF3-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26791483},
      doi          = {10.1007/s00018-016-2130-4},
      url          = {https://inrepo02.dkfz.de/record/132584},
}