Journal Article

DKFZ-2018-00250

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The DNA damage-induced cell death response: a roadmap to kill cancer cells.

Matt, S. (First author)DKFZ* ; Hofmann, T. (Last author)DKFZ*

2016
Birkhäuser Basel

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Please use a persistent id in citations: doi:10.1007/s00018-016-2130-4

Abstract: Upon massive DNA damage cells fail to undergo productive DNA repair and trigger the cell death response. Resistance to cell death is linked to cellular transformation and carcinogenesis as well as radio- and chemoresistance, making the underlying signaling pathways a promising target for therapeutic intervention. Diverse DNA damage-induced cell death pathways are operative in mammalian cells and finally culminate in the induction of programmed cell death via activation of apoptosis or necroptosis. These signaling routes affect nuclear, mitochondria- and plasma membrane-associated key molecules to activate the apoptotic or necroptotic response. In this review, we highlight the main signaling pathways, molecular players and mechanisms guiding the DNA damage-induced cell death response.

Note: review, ZMBH Allianz

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Contributing Institute(s):

1. Zelluläre Seneszenz (A210)
2. Epigenetik (A130)

Research Program(s):

1. 311 - Signalling pathways, cell and tumor biology (POF3-311) (POF3-311)

Appears in the scientific report 2016

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Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Current Contents - Life Sciences ; Ebsco Academic Search ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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