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@ARTICLE{Niesporek:132663,
      author       = {S. Niesporek$^*$ and R. Umathum$^*$ and J. Lommen$^*$ and
                      N. Behl$^*$ and D. Paech$^*$ and P. Bachert$^*$ and M.
                      Ladd$^*$ and A. Nagel$^*$},
      title        = {{R}eproducibility of {CMRO}2determination using
                      dynamic17{O} {MRI}.},
      journal      = {Magnetic resonance in medicine},
      volume       = {79},
      number       = {6},
      issn         = {0740-3194},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2018-00323},
      pages        = {2923 - 2934},
      year         = {2018},
      abstract     = {To assess the reproducibility of17O MRI-based determination
                      of the cerebral metabolic rate of oxygen consumption (CMRO2)
                      in healthy volunteers. To assess the influence of image
                      acquisition and reconstruction parameters on dynamic
                      quantification of functional parameters such as
                      CMRO2.Dynamic17O MRI data were simulated and used to
                      investigate influences of temporal resolution (Δt) and
                      partial volume correction (PVC) on the determination of
                      CMRO2. Three healthy volunteers were examined in two
                      separate examinations. In vivo17O MRI measurements were
                      conducted with a nominal spatial resolution of
                      (7.5 mm)3using a density-adapted radial sequence with
                      golden angle acquisition scheme. In each measurement,
                      4.0 ± 0.1 L of $70\%-enriched17O$ gas were
                      administered using a rebreathing system. Data were corrected
                      with a PVC algorithm, and CMRO2was determined in gray matter
                      (GM) and white matter (WM) compartments using a three-phase
                      metabolic model (baseline,17O inhalation, decay
                      phase).Comparison with the ground truth of simulations
                      revealed improved CMRO2determination after application of
                      PVC and with Δt ≤ 2:00 min. Evaluation of in vivo
                      data yields to CMRO2,GM = 2.31 ± 0.1 μmol/g/min
                      and to CMRO2,WM = 0.69 ± 0.04 μmol/g/min with
                      coefficients of variation (CoV) of $0.3-5.5\%$ and
                      $4.3-5.0\%$ for intra-volunteer and inter-volunteer data,
                      respectively.This in vivo17O inhalation study demonstrated
                      that the proposed experimental setup enables reproducible
                      determination of CMRO2in healthy volunteers. Magn Reson Med
                      79:2923-2934, 2018. © 2017 International Society for
                      Magnetic Resonance in Medicine.},
      cin          = {E020 / E010},
      ddc          = {610},
      cid          = {I:(DE-He78)E020-20160331 / I:(DE-He78)E010-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29030876},
      doi          = {10.1002/mrm.26952},
      url          = {https://inrepo02.dkfz.de/record/132663},
}