Journal Article

DKFZ-2018-00323

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Reproducibility of CMRO2determination using dynamic17O MRI.

Niesporek, S. (First author)DKFZ* ; Umathum, R.DKFZ* ; Lommen, J.DKFZ* ; Behl, N.DKFZ* ; Paech, D.DKFZ* ; Bachert, P.DKFZ* ; Ladd, M.DKFZ* ; Nagel, A. (Last author)DKFZ*

2018
Wiley-Liss New York, NY [u.a.]

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Please use a persistent id in citations: doi:10.1002/mrm.26952

Abstract: To assess the reproducibility of17O MRI-based determination of the cerebral metabolic rate of oxygen consumption (CMRO2) in healthy volunteers. To assess the influence of image acquisition and reconstruction parameters on dynamic quantification of functional parameters such as CMRO2.Dynamic17O MRI data were simulated and used to investigate influences of temporal resolution (Δt) and partial volume correction (PVC) on the determination of CMRO2. Three healthy volunteers were examined in two separate examinations. In vivo17O MRI measurements were conducted with a nominal spatial resolution of (7.5 mm)3using a density-adapted radial sequence with golden angle acquisition scheme. In each measurement, 4.0 ± 0.1 L of 70%-enriched17O gas were administered using a rebreathing system. Data were corrected with a PVC algorithm, and CMRO2was determined in gray matter (GM) and white matter (WM) compartments using a three-phase metabolic model (baseline,17O inhalation, decay phase).Comparison with the ground truth of simulations revealed improved CMRO2determination after application of PVC and with Δt ≤ 2:00 min. Evaluation of in vivo data yields to CMRO2,GM = 2.31 ± 0.1 μmol/g/min and to CMRO2,WM = 0.69 ± 0.04 μmol/g/min with coefficients of variation (CoV) of 0.3-5.5% and 4.3-5.0% for intra-volunteer and inter-volunteer data, respectively.This in vivo17O inhalation study demonstrated that the proposed experimental setup enables reproducible determination of CMRO2in healthy volunteers. Magn Reson Med 79:2923-2934, 2018. © 2017 International Society for Magnetic Resonance in Medicine.

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Contributing Institute(s):

1. Medizinische Physik in der Radiologie (E020)
2. Radiologie (E010)

Research Program(s):

1. 315 - Imaging and radiooncology (POF3-315) (POF3-315)

Appears in the scientific report 2018

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Database coverage:
; BIOSIS Previews ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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