000132799 001__ 132799
000132799 005__ 20240229105033.0
000132799 0247_ $$2doi$$a10.1038/s41416-018-0011-3
000132799 0247_ $$2pmid$$apmid:29555990
000132799 0247_ $$2ISSN$$a0007-0920
000132799 0247_ $$2ISSN$$a1532-1827
000132799 0247_ $$2altmetric$$aaltmetric:34589931
000132799 037__ $$aDKFZ-2018-00443
000132799 041__ $$aeng
000132799 082__ $$a610
000132799 1001_ $$00000-0003-3714-8386$$aDixon-Suen, Suzanne C$$b0
000132799 245__ $$aAdult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study.
000132799 260__ $$aEdinburgh$$bNature Publ. Group$$c2018
000132799 3367_ $$2DRIVER$$aarticle
000132799 3367_ $$2DataCite$$aOutput Types/Journal article
000132799 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1525765895_18768
000132799 3367_ $$2BibTeX$$aARTICLE
000132799 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000132799 3367_ $$00$$2EndNote$$aJournal Article
000132799 520__ $$aObservational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias.We pooled data from 39 Ovarian Cancer Association Consortium studies (16,395 cases; 23,003 controls). We applied two-stage predictor-substitution MR, using a weighted genetic risk score combining 609 single-nucleotide polymorphisms. Study-specific odds ratios (OR) and 95% confidence intervals (CI) for the association between genetically predicted height and risk were pooled using random-effects meta-analysis.Greater genetically predicted height was associated with increased ovarian cancer risk overall (pooled-OR (pOR) = 1.06; 95% CI: 1.01-1.11 per 5 cm increase in height), and separately for invasive (pOR = 1.06; 95% CI: 1.01-1.11) and borderline (pOR = 1.15; 95% CI: 1.02-1.29) tumours.Women with a genetic propensity to being taller have increased risk of ovarian cancer. This suggests genes influencing height are involved in pathways promoting ovarian carcinogenesis.
000132799 536__ $$0G:(DE-HGF)POF3-313$$a313 - Cancer risk factors and prevention (POF3-313)$$cPOF3-313$$fPOF III$$x0
000132799 588__ $$aDataset connected to CrossRef, PubMed,
000132799 7001_ $$aNagle, Christina M$$b1
000132799 7001_ $$aThrift, Aaron P$$b2
000132799 7001_ $$aPharoah, Paul D P$$b3
000132799 7001_ $$aEwing, Ailith$$b4
000132799 7001_ $$aPearce, Celeste Leigh$$b5
000132799 7001_ $$00000-0003-1226-070X$$aZheng, Wei$$b6
000132799 7001_ $$aGroup, Australian Ovarian Cancer Study$$b7$$eCollaboration Author
000132799 7001_ $$aChenevix-Trench, Georgia$$b8
000132799 7001_ $$aFasching, Peter A$$b9
000132799 7001_ $$aBeckmann, Matthias W$$b10
000132799 7001_ $$aLambrechts, Diether$$b11
000132799 7001_ $$aVergote, Ignace$$b12
000132799 7001_ $$aLambrechts, Sandrina$$b13
000132799 7001_ $$aVan Nieuwenhuysen, Els$$b14
000132799 7001_ $$aRossing, Mary Anne$$b15
000132799 7001_ $$aDoherty, Jennifer A$$b16
000132799 7001_ $$aWicklund, Kristine G$$b17
000132799 7001_ $$0P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aChang-Claude, Jenny$$b18$$udkfz
000132799 7001_ $$aJung, Audrey Y$$b19
000132799 7001_ $$aMoysich, Kirsten B$$b20
000132799 7001_ $$aOdunsi, Kunle$$b21
000132799 7001_ $$aGoodman, Marc T$$b22
000132799 7001_ $$aWilkens, Lynne R$$b23
000132799 7001_ $$aThompson, Pamela J$$b24
000132799 7001_ $$aShvetsov, Yurii B$$b25
000132799 7001_ $$aDörk, Thilo$$b26
000132799 7001_ $$aPark-Simon, Tjoung-Won$$b27
000132799 7001_ $$aHillemanns, Peter$$b28
000132799 7001_ $$aBogdanova, Natalia$$b29
000132799 7001_ $$aButzow, Ralf$$b30
000132799 7001_ $$aNevanlinna, Heli$$b31
000132799 7001_ $$aPelttari, Liisa M$$b32
000132799 7001_ $$aLeminen, Arto$$b33
000132799 7001_ $$aModugno, Francesmary$$b34
000132799 7001_ $$aNess, Roberta B$$b35
000132799 7001_ $$aEdwards, Robert P$$b36
000132799 7001_ $$aKelley, Joseph L$$b37
000132799 7001_ $$aHeitz, Florian$$b38
000132799 7001_ $$adu Bois, Andreas$$b39
000132799 7001_ $$aHarter, Philipp$$b40
000132799 7001_ $$aSchwaab, Ira$$b41
000132799 7001_ $$aKarlan, Beth Y$$b42
000132799 7001_ $$aLester, Jenny$$b43
000132799 7001_ $$aOrsulic, Sandra$$b44
000132799 7001_ $$aRimel, Bobbie J$$b45
000132799 7001_ $$aKjær, Susanne K$$b46
000132799 7001_ $$aHøgdall, Estrid$$b47
000132799 7001_ $$aJensen, Allan$$b48
000132799 7001_ $$aGoode, Ellen L$$b49
000132799 7001_ $$aFridley, Brooke L$$b50
000132799 7001_ $$aCunningham, Julie M$$b51
000132799 7001_ $$aWinham, Stacey J$$b52
000132799 7001_ $$aGiles, Graham G$$b53
000132799 7001_ $$aBruinsma, Fiona$$b54
000132799 7001_ $$aMilne, Roger L$$b55
000132799 7001_ $$aSouthey, Melissa C$$b56
000132799 7001_ $$aHildebrandt, Michelle A T$$b57
000132799 7001_ $$aWu, Xifeng$$b58
000132799 7001_ $$aLu, Karen H$$b59
000132799 7001_ $$aLiang, Dong$$b60
000132799 7001_ $$aLevine, Douglas A$$b61
000132799 7001_ $$aBisogna, Maria$$b62
000132799 7001_ $$aSchildkraut, Joellen M$$b63
000132799 7001_ $$aBerchuck, Andrew$$b64
000132799 7001_ $$aCramer, Daniel W$$b65
000132799 7001_ $$aTerry, Kathryn L$$b66
000132799 7001_ $$aBandera, Elisa V$$b67
000132799 7001_ $$aOlson, Sara H$$b68
000132799 7001_ $$aSalvesen, Helga B$$b69
000132799 7001_ $$aThomsen, Liv Cecilie Vestrheim$$b70
000132799 7001_ $$aKopperud, Reidun K$$b71
000132799 7001_ $$aBjorge, Line$$b72
000132799 7001_ $$aKiemeney, Lambertus A$$b73
000132799 7001_ $$aMassuger, Leon F A G$$b74
000132799 7001_ $$aPejovic, Tanja$$b75
000132799 7001_ $$aBruegl, Amanda$$b76
000132799 7001_ $$aCook, Linda S$$b77
000132799 7001_ $$aLe, Nhu D$$b78
000132799 7001_ $$aSwenerton, Kenneth D$$b79
000132799 7001_ $$aBrooks-Wilson, Angela$$b80
000132799 7001_ $$aKelemen, Linda E$$b81
000132799 7001_ $$aLubiński, Jan$$b82
000132799 7001_ $$aHuzarski, Tomasz$$b83
000132799 7001_ $$aGronwald, Jacek$$b84
000132799 7001_ $$aMenkiszak, Janusz$$b85
000132799 7001_ $$aWentzensen, Nicolas$$b86
000132799 7001_ $$00000-0003-3853-8562$$aBrinton, Louise$$b87
000132799 7001_ $$aYang, Hannah$$b88
000132799 7001_ $$aLissowska, Jolanta$$b89
000132799 7001_ $$aHøgdall, Claus K$$b90
000132799 7001_ $$aLundvall, Lene$$b91
000132799 7001_ $$aSong, Honglin$$b92
000132799 7001_ $$aTyrer, Jonathan P$$b93
000132799 7001_ $$aCampbell, Ian$$b94
000132799 7001_ $$aEccles, Diana$$b95
000132799 7001_ $$aPaul, James$$b96
000132799 7001_ $$00000-0002-5000-1680$$aGlasspool, Rosalind$$b97
000132799 7001_ $$aSiddiqui, Nadeem$$b98
000132799 7001_ $$aWhittemore, Alice S$$b99
000132799 7001_ $$aSieh, Weiva$$b100
000132799 7001_ $$aMcGuire, Valerie$$b101
000132799 7001_ $$aRothstein, Joseph H$$b102
000132799 7001_ $$aNarod, Steven A$$b103
000132799 7001_ $$aPhelan, Catherine$$b104
000132799 7001_ $$aRisch, Harvey A$$b105
000132799 7001_ $$aMcLaughlin, John R$$b106
000132799 7001_ $$aAnton-Culver, Hoda$$b107
000132799 7001_ $$aZiogas, Argyrios$$b108
000132799 7001_ $$aMenon, Usha$$b109
000132799 7001_ $$aGayther, Simon A$$b110
000132799 7001_ $$aRamus, Susan J$$b111
000132799 7001_ $$aGentry-Maharaj, Aleksandra$$b112
000132799 7001_ $$aWu, Anna H$$b113
000132799 7001_ $$aPike, Malcolm C$$b114
000132799 7001_ $$aTseng, Chiu-Chen$$b115
000132799 7001_ $$aKupryjanczyk, Jolanta$$b116
000132799 7001_ $$aDansonka-Mieszkowska, Agnieszka$$b117
000132799 7001_ $$aBudzilowska, Agnieszka$$b118
000132799 7001_ $$aRzepecka, Iwona K$$b119
000132799 7001_ $$aWebb, Penelope M$$b120
000132799 7001_ $$aConsortium, Ovarian Cancer Association$$b121$$eCollaboration Author
000132799 773__ $$0PERI:(DE-600)2002452-6$$a10.1038/s41416-018-0011-3$$gVol. 118, no. 8, p. 1123 - 1129$$n8$$p1123 - 1129$$tBritish journal of cancer$$v118$$x1532-1827$$y2018
000132799 909CO $$ooai:inrepo02.dkfz.de:132799$$pVDB
000132799 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aDeutsches Krebsforschungszentrum$$b18$$kDKFZ
000132799 9131_ $$0G:(DE-HGF)POF3-313$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vCancer risk factors and prevention$$x0
000132799 9141_ $$y2018
000132799 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bBRIT J CANCER : 2015
000132799 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000132799 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000132799 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000132799 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search
000132799 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC
000132799 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000132799 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000132799 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000132799 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000132799 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine
000132799 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000132799 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000132799 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bBRIT J CANCER : 2015
000132799 9201_ $$0I:(DE-He78)C020-20160331$$kC020$$lEpidemiologie von Krebserkrankungen$$x0
000132799 980__ $$ajournal
000132799 980__ $$aVDB
000132799 980__ $$aI:(DE-He78)C020-20160331
000132799 980__ $$aUNRESTRICTED