Journal Article

DKFZ-2018-00443

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study.

Dixon-Suen, S. C. ; Nagle, C. M. ; Thrift, A. P. ; Pharoah, P. D. P. ; Ewing, A. ; Pearce, C. L. ; Zheng, W. ; Group, A. O. C. S. (Collaboration Author) ; Chenevix-Trench, G. ; Fasching, P. A. ; Beckmann, M. W. ; Lambrechts, D. ; Vergote, I. ; Lambrechts, S. ; Van Nieuwenhuysen, E. ; Rossing, M. A. ; Doherty, J. A. ; Wicklund, K. G. ; Chang-Claude, J.DKFZ* ; Jung, A. Y. ; Moysich, K. B. ; Odunsi, K. ; Goodman, M. T. ; Wilkens, L. R. ; Thompson, P. J. ; Shvetsov, Y. B. ; Dörk, T. ; Park-Simon, T.-W. ; Hillemanns, P. ; Bogdanova, N. ; Butzow, R. ; Nevanlinna, H. ; Pelttari, L. M. ; Leminen, A. ; Modugno, F. ; Ness, R. B. ; Edwards, R. P. ; Kelley, J. L. ; Heitz, F. ; du Bois, A. ; Harter, P. ; Schwaab, I. ; Karlan, B. Y. ; Lester, J. ; Orsulic, S. ; Rimel, B. J. ; Kjær, S. K. ; Høgdall, E. ; Jensen, A. ; Goode, E. L. ; Fridley, B. L. ; Cunningham, J. M. ; Winham, S. J. ; Giles, G. G. ; Bruinsma, F. ; Milne, R. L. ; Southey, M. C. ; Hildebrandt, M. A. T. ; Wu, X. ; Lu, K. H. ; Liang, D. ; Levine, D. A. ; Bisogna, M. ; Schildkraut, J. M. ; Berchuck, A. ; Cramer, D. W. ; Terry, K. L. ; Bandera, E. V. ; Olson, S. H. ; Salvesen, H. B. ; Thomsen, L. C. V. ; Kopperud, R. K. ; Bjorge, L. ; Kiemeney, L. A. ; Massuger, L. F. A. G. ; Pejovic, T. ; Bruegl, A. ; Cook, L. S. ; Le, N. D. ; Swenerton, K. D. ; Brooks-Wilson, A. ; Kelemen, L. E. ; Lubiński, J. ; Huzarski, T. ; Gronwald, J. ; Menkiszak, J. ; Wentzensen, N. ; Brinton, L. ; Yang, H. ; Lissowska, J. ; Høgdall, C. K. ; Lundvall, L. ; Song, H. ; Tyrer, J. P. ; Campbell, I. ; Eccles, D. ; Paul, J. ; Glasspool, R. ; Siddiqui, N. ; Whittemore, A. S. ; Sieh, W. ; McGuire, V. ; Rothstein, J. H. ; Narod, S. A. ; Phelan, C. ; Risch, H. A. ; McLaughlin, J. R. ; Anton-Culver, H. ; Ziogas, A. ; Menon, U. ; Gayther, S. A. ; Ramus, S. J. ; Gentry-Maharaj, A. ; Wu, A. H. ; Pike, M. C. ; Tseng, C.-C. ; Kupryjanczyk, J. ; Dansonka-Mieszkowska, A. ; Budzilowska, A. ; Rzepecka, I. K. ; Webb, P. M. ; Consortium, O. C. A. (Collaboration Author)

2018
Nature Publ. Group Edinburgh

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Please use a persistent id in citations: doi:10.1038/s41416-018-0011-3

Abstract: Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias.We pooled data from 39 Ovarian Cancer Association Consortium studies (16,395 cases; 23,003 controls). We applied two-stage predictor-substitution MR, using a weighted genetic risk score combining 609 single-nucleotide polymorphisms. Study-specific odds ratios (OR) and 95% confidence intervals (CI) for the association between genetically predicted height and risk were pooled using random-effects meta-analysis.Greater genetically predicted height was associated with increased ovarian cancer risk overall (pooled-OR (pOR) = 1.06; 95% CI: 1.01-1.11 per 5 cm increase in height), and separately for invasive (pOR = 1.06; 95% CI: 1.01-1.11) and borderline (pOR = 1.15; 95% CI: 1.02-1.29) tumours.Women with a genetic propensity to being taller have increased risk of ovarian cancer. This suggests genes influencing height are involved in pathways promoting ovarian carcinogenesis.

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Contributing Institute(s):

1. Epidemiologie von Krebserkrankungen (C020)

Research Program(s):

1. 313 - Cancer risk factors and prevention (POF3-313) (POF3-313)

Appears in the scientific report 2018

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Database coverage:
; BIOSIS Previews ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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