%0 Journal Article
%A Vijayakrishnan, Jayaram
%A Studd, James
%A Broderick, Peter
%A Kinnersley, Ben
%A Holroyd, Amy
%A Law, Philip J
%A Kumar, Rajiv
%A Allan, James M
%A Harrison, Christine J
%A Moorman, Anthony V
%A Vora, Ajay
%A Roman, Eve
%A Rachakonda, Sivaramakrishna
%A Kinsey, Sally E
%A Sheridan, Eamonn
%A Thompson, Pamela D
%A Irving, Julie A
%A Koehler, Rolf
%A Hoffmann, Per
%A Nöthen, Markus M
%A Heilmann-Heimbach, Stefanie
%A Jöckel, Karl-Heinz
%A Easton, Douglas F
%A Pharaoh, Paul D P
%A Dunning, Alison M
%A Peto, Julian
%A Canzian, Frederico
%A Swerdlow, Anthony
%A Eeles, Rosalind A
%A Kote-Jarai, ZSofia
%A Muir, Kenneth
%A Pashayan, Nora
%A Greaves, Mel
%A Zimmerman, Martin
%A Bartram, Claus R
%A Schrappe, Martin
%A Stanulla, Martin
%A Hemminki, Kari
%A Houlston, Richard S
%A Henderson, Brian E
%A Haiman, Christopher A
%A Benlloch, Sara
%A Schumacher, Fredrick R
%A Olama, Ali Amin Al
%A Berndt, Sonja I
%A Conti, David V
%A Wiklund, Fredrik
%A Chanock, Stephen
%A Stevens, Victoria L
%A Tangen, Catherine M
%A Batra, Jyotsna
%A Clements, Judith
%A Gronberg, Henrik
%A Schleutker, Johanna
%A Albanes, Demetrius
%A Weinstein, Stephanie
%A Wolk, Alicja
%A West, Catharine
%A Mucci, Lorelei
%A Cancel-Tassin, Géraldine
%A Koutros, Stella
%A Sorensen, Karina Dalsgaard
%A Maehle, Lovise
%A Neal, David E
%A Travis, Ruth C
%A Hamilton, Robert J
%A Ingles, Sue Ann
%A Rosenstein, Barry
%A Lu, Yong-Jie
%A Giles, Graham G
%A Kibel, Adam S
%A Vega, Ana
%A Kogevinas, Manolis
%A Penney, Kathryn L
%A Park, Jong Y
%A Stanford, Janet L
%A Cybulski, Cezary
%A Nordestgaard, Børge G
%A Brenner, Hermann
%A Maier, Christiane
%A Kim, Jeri
%A John, Esther M
%A Teixeira, Manuel R
%A Neuhausen, Susan L
%A De Ruyck, Kim
%A Razack, Azad
%A Newcomb, Lisa F
%A Lessel, Davor
%A Kaneva, Radka
%A Usmani, Nawaid
%A Claessens, Frank
%A Townsend, Paul A
%A Dominguez, Manuela Gago
%A Roobol, Monique J
%A Menegaux, Florence
%T Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia.
%J Nature Communications
%V 9
%N 1
%@ 2041-1723
%C London
%I Nature Publishing Group
%M DKFZ-2018-00511
%P 1340
%D 2018
%X Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform a GWAS and conduct a meta-analysis with two existing GWAS, totaling 2442 cases and 14,609 controls. We identify risk loci for BCP-ALL at 8q24.21 (rs28665337, P = 3.86 × 10-9, odds ratio (OR) = 1.34) and for ETV6-RUNX1 fusion-positive BCP-ALL at 2q22.3 (rs17481869, P = 3.20 × 10-8, OR = 2.14). Our findings provide further insights into genetic susceptibility to ALL and its biology.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:29632299
%2 pmc:PMC5890276
%R 10.1038/s41467-018-03178-z
%U https://inrepo02.dkfz.de/record/132868