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000132868 037__ $$aDKFZ-2018-00511
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000132868 1001_ $$aVijayakrishnan, Jayaram$$b0
000132868 245__ $$aGenome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia.
000132868 260__ $$aLondon$$bNature Publishing Group$$c2018
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000132868 520__ $$aGenome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform a GWAS and conduct a meta-analysis with two existing GWAS, totaling 2442 cases and 14,609 controls. We identify risk loci for BCP-ALL at 8q24.21 (rs28665337, P = 3.86 × 10-9, odds ratio (OR) = 1.34) and for ETV6-RUNX1 fusion-positive BCP-ALL at 2q22.3 (rs17481869, P = 3.20 × 10-8, OR = 2.14). Our findings provide further insights into genetic susceptibility to ALL and its biology.
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000132868 7001_ $$00000-0001-9663-4611$$aLaw, Philip J$$b5
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000132868 7001_ $$aHarrison, Christine J$$b8
000132868 7001_ $$aMoorman, Anthony V$$b9
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000132868 7001_ $$aIrving, Julie A$$b16
000132868 7001_ $$aKoehler, Rolf$$b17
000132868 7001_ $$aHoffmann, Per$$b18
000132868 7001_ $$aNöthen, Markus M$$b19
000132868 7001_ $$aHeilmann-Heimbach, Stefanie$$b20
000132868 7001_ $$aJöckel, Karl-Heinz$$b21
000132868 7001_ $$00000-0003-2444-3247$$aEaston, Douglas F$$b22
000132868 7001_ $$00000-0001-8494-732X$$aPharaoh, Paul D P$$b23
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000132868 7001_ $$aPeto, Julian$$b25
000132868 7001_ $$00000-0002-4261-4583$$aCanzian, Frederico$$b26
000132868 7001_ $$aSwerdlow, Anthony$$b27
000132868 7001_ $$00000-0002-3698-6241$$aEeles, Rosalind A$$b28
000132868 7001_ $$aKote-Jarai, ZSofia$$b29
000132868 7001_ $$00000-0001-6429-988X$$aMuir, Kenneth$$b30
000132868 7001_ $$00000-0003-0843-2468$$aPashayan, Nora$$b31
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000132868 7001_ $$aZimmerman, Martin$$b33
000132868 7001_ $$aBartram, Claus R$$b34
000132868 7001_ $$aSchrappe, Martin$$b35
000132868 7001_ $$aStanulla, Martin$$b36
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000132868 7001_ $$aWiklund, Fredrik$$b47
000132868 7001_ $$aChanock, Stephen$$b48
000132868 7001_ $$aStevens, Victoria L$$b49
000132868 7001_ $$aTangen, Catherine M$$b50
000132868 7001_ $$aBatra, Jyotsna$$b51
000132868 7001_ $$aClements, Judith$$b52
000132868 7001_ $$aGronberg, Henrik$$b53
000132868 7001_ $$aSchleutker, Johanna$$b54
000132868 7001_ $$aAlbanes, Demetrius$$b55
000132868 7001_ $$aWeinstein, Stephanie$$b56
000132868 7001_ $$aWolk, Alicja$$b57
000132868 7001_ $$aWest, Catharine$$b58
000132868 7001_ $$aMucci, Lorelei$$b59
000132868 7001_ $$aCancel-Tassin, Géraldine$$b60
000132868 7001_ $$aKoutros, Stella$$b61
000132868 7001_ $$aSorensen, Karina Dalsgaard$$b62
000132868 7001_ $$aMaehle, Lovise$$b63
000132868 7001_ $$aNeal, David E$$b64
000132868 7001_ $$aTravis, Ruth C$$b65
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000132868 7001_ $$aIngles, Sue Ann$$b67
000132868 7001_ $$aRosenstein, Barry$$b68
000132868 7001_ $$aLu, Yong-Jie$$b69
000132868 7001_ $$aGiles, Graham G$$b70
000132868 7001_ $$aKibel, Adam S$$b71
000132868 7001_ $$aVega, Ana$$b72
000132868 7001_ $$aKogevinas, Manolis$$b73
000132868 7001_ $$aPenney, Kathryn L$$b74
000132868 7001_ $$aPark, Jong Y$$b75
000132868 7001_ $$aStanford, Janet L$$b76
000132868 7001_ $$aCybulski, Cezary$$b77
000132868 7001_ $$aNordestgaard, Børge G$$b78
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000132868 7001_ $$aKim, Jeri$$b81
000132868 7001_ $$aJohn, Esther M$$b82
000132868 7001_ $$aTeixeira, Manuel R$$b83
000132868 7001_ $$aNeuhausen, Susan L$$b84
000132868 7001_ $$aDe Ruyck, Kim$$b85
000132868 7001_ $$aRazack, Azad$$b86
000132868 7001_ $$aNewcomb, Lisa F$$b87
000132868 7001_ $$aLessel, Davor$$b88
000132868 7001_ $$aKaneva, Radka$$b89
000132868 7001_ $$aUsmani, Nawaid$$b90
000132868 7001_ $$aClaessens, Frank$$b91
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