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@ARTICLE{Wenz:132902,
      author       = {D. Wenz and A. Kuehne and T. Huelnhagen and A. Nagel$^*$
                      and H. Waiczies and O. Weinberger and C. Oezerdem and O.
                      Stachs and S. Langner and E. Seeliger and B. Flemming and R.
                      Hodge and T. Niendorf},
      title        = {{M}illimeter spatial resolution in vivo sodium {MRI} of the
                      human eye at 7 {T} using a dedicated radiofrequency
                      transceiver array.},
      journal      = {Magnetic resonance in medicine},
      volume       = {80},
      number       = {2},
      issn         = {0740-3194},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2018-00544},
      pages        = {672 - 684},
      year         = {2018},
      abstract     = {The aim of this study was to achieve millimeter spatial
                      resolution sodium in vivo MRI of the human eye at 7 T
                      using a dedicated six-channel transceiver array. We present
                      a detailed description of the radiofrequency coil design,
                      along with electromagnetic field and specific absorption
                      ratio simulations, data validation, and in vivo
                      application.Electromagnetic field and specific absorption
                      ratio simulations were performed. Transmit field uniformity
                      was optimized by using a multi-objective genetic algorithm.
                      Transmit field mapping was conducted using a phase-sensitive
                      method. An in vivo feasibility study was carried out with
                      3-dimensional density-adapted projection reconstruction
                      imaging technique.Measured transmit field distribution
                      agrees well with the one obtained from simulations. The
                      specific absorption ratio simulations confirm that the
                      radiofrequency coil is safe for clinical use. Our
                      radiofrequency coil is light and conforms to an average
                      human head. High spatial resolution (nominal 1.4 and
                      1.0 mm isotropic) sodium in vivo images of the human eye
                      were acquired within scan times suitable for clinical
                      applications (∼ 10 min).Three most important eye
                      compartments in the context of sodium physiology were
                      clearly delineated in all of the images: the vitreous humor,
                      the aqueous humor, and the lens. Our results provide
                      encouragement for further clinical studies. The implications
                      for research into eye diseases including ocular melanoma,
                      cataract, and glaucoma are discussed. Magn Reson Med
                      80:672-684, 2018. © 2018 International Society for Magnetic
                      Resonance in Medicine.},
      cin          = {E020},
      ddc          = {610},
      cid          = {I:(DE-He78)E020-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29327365},
      doi          = {10.1002/mrm.27053},
      url          = {https://inrepo02.dkfz.de/record/132902},
}