%0 Journal Article
%A Butt, Julia Anna
%A Jenab, Mazda
%A Willhauck-Fleckenstein, Martina
%A Michel, Angelika
%A Pawlita, Michael
%A Kyrø, Cecilie
%A Tjønneland, Anne
%A Boutron-Ruault, Marie-Christine
%A Carbonnel, Franck
%A Severi, Gianluca
%A Kaaks, Rudolf
%A Kühn, Tilman
%A Boeing, Heiner
%A Trichopoulou, Antonia
%A la Vecchia, Carlo
%A Karakatsani, Anna
%A Panico, Salvatore
%A Tumino, Rosario
%A Agnoli, Claudia
%A Palli, Domenico
%A Sacerdote, Carlotta
%A Bueno-de-Mesquita, H B As
%A Weiderpass, Elisabete
%A Sánchez, Maria-José
%A Bonet Bonet, Catalina
%A Huerta, José María
%A Ardanaz, Eva
%A Bradbury, Kathryn
%A Gunter, Marc
%A Murphy, Neil
%A Freisling, Heinz
%A Riboli, Elio
%A Tsilidis, Kostas
%A Aune, Dagfinn
%A Waterboer, Tim
%A Hughes, David J
%T Prospective evaluation of antibody response to Streptococcus gallolyticus and risk of colorectal cancer.
%J International journal of cancer
%V 143
%N 2
%@ 0020-7136
%C Bognor Regis
%I Wiley-Liss
%M DKFZ-2018-00687
%P 245 - 252
%D 2018
%X The gut microbiome is increasingly implicated in colorectal cancer (CRC) development. A subgroup of patients diagnosed with CRC show high antibody responses to Streptococcus gallolyticus subspecies gallolyticus (SGG). However, it is unclear whether the association is also present pre-diagnostically. We assessed the association of antibody responses to SGG proteins in pre-diagnostic serum samples with CRC risk in a case-control study nested within a prospective cohort. Pre-diagnostic serum samples from 485 first incident CRC cases (mean time between blood draw and diagnosis 3.4 years) and 485 matched controls in the European Prospective Investigation into Nutrition and Cancer (EPIC) study were analyzed for antibody responses to 11 SGG proteins using multiplex serology. Odds ratios (OR) and 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:29377173
%R 10.1002/ijc.31283
%U https://inrepo02.dkfz.de/record/135950