Journal Article

DKFZ-2018-00687

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Prospective evaluation of antibody response to Streptococcus gallolyticus and risk of colorectal cancer.

Butt, J. A. (First author)DKFZ* ; Jenab, M. ; Willhauck-Fleckenstein, M.DKFZ* ; Michel, A.DKFZ* ; Pawlita, M.DKFZ* ; Kyrø, C. ; Tjønneland, A. ; Boutron-Ruault, M.-C. ; Carbonnel, F. ; Severi, G. ; Kaaks, R.DKFZ* ; Kühn, T.DKFZ* ; Boeing, H. ; Trichopoulou, A. ; la Vecchia, C. ; Karakatsani, A. ; Panico, S. ; Tumino, R. ; Agnoli, C. ; Palli, D. ; Sacerdote, C. ; Bueno-de-Mesquita, H. B. A. ; Weiderpass, E. ; Sánchez, M.-J. ; Bonet Bonet, C. ; Huerta, J. M. ; Ardanaz, E. ; Bradbury, K. ; Gunter, M. ; Murphy, N. ; Freisling, H. ; Riboli, E. ; Tsilidis, K. ; Aune, D. ; Waterboer, T. (Last author)DKFZ* ; Hughes, D. J.

2018
Wiley-Liss Bognor Regis

This record in other databases:  

Please use a persistent id in citations: doi:10.1002/ijc.31283

Abstract: The gut microbiome is increasingly implicated in colorectal cancer (CRC) development. A subgroup of patients diagnosed with CRC show high antibody responses to Streptococcus gallolyticus subspecies gallolyticus (SGG). However, it is unclear whether the association is also present pre-diagnostically. We assessed the association of antibody responses to SGG proteins in pre-diagnostic serum samples with CRC risk in a case-control study nested within a prospective cohort. Pre-diagnostic serum samples from 485 first incident CRC cases (mean time between blood draw and diagnosis 3.4 years) and 485 matched controls in the European Prospective Investigation into Nutrition and Cancer (EPIC) study were analyzed for antibody responses to 11 SGG proteins using multiplex serology. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using multivariable conditional logistic regression models. Antibody positivity for any of the 11 SGG proteins was significantly associated with CRC risk with 56% positive controls compared to 63% positive cases (OR: 1.36, 95% CI: 1.04-1.77). Positivity for two or more proteins of a previously identified SGG 6-marker panel with greater CRC-specificity was also observed among 9% of controls compared to 17% of CRC cases, corresponding to a significantly increased CRC risk (OR: 2.17, 95% CI: 1.44-3.27). In this prospective nested case-control study, we observed a positive association between antibody responses to SGG and CRC development in serum samples taken before evident disease onset. Further work is required to establish the possibly etiological significance of these observations and whether SGG serology may be applicable for CRC risk stratification.

---

Contributing Institute(s):

1. Infektionen und Krebs-Epidemiologie (F022)
2. Infektionen und Krebs-Epidemiologie (F020)
3. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 316 - Infections and cancer (POF3-316) (POF3-316)

Appears in the scientific report 2018

---

Database coverage:
; BIOSIS Previews ; Current Contents - Life Sciences ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

---