TY  - JOUR
AU  - Butt, Julia Anna
AU  - Jenab, Mazda
AU  - Willhauck-Fleckenstein, Martina
AU  - Michel, Angelika
AU  - Pawlita, Michael
AU  - Kyrø, Cecilie
AU  - Tjønneland, Anne
AU  - Boutron-Ruault, Marie-Christine
AU  - Carbonnel, Franck
AU  - Severi, Gianluca
AU  - Kaaks, Rudolf
AU  - Kühn, Tilman
AU  - Boeing, Heiner
AU  - Trichopoulou, Antonia
AU  - la Vecchia, Carlo
AU  - Karakatsani, Anna
AU  - Panico, Salvatore
AU  - Tumino, Rosario
AU  - Agnoli, Claudia
AU  - Palli, Domenico
AU  - Sacerdote, Carlotta
AU  - Bueno-de-Mesquita, H B As
AU  - Weiderpass, Elisabete
AU  - Sánchez, Maria-José
AU  - Bonet Bonet, Catalina
AU  - Huerta, José María
AU  - Ardanaz, Eva
AU  - Bradbury, Kathryn
AU  - Gunter, Marc
AU  - Murphy, Neil
AU  - Freisling, Heinz
AU  - Riboli, Elio
AU  - Tsilidis, Kostas
AU  - Aune, Dagfinn
AU  - Waterboer, Tim
AU  - Hughes, David J
TI  - Prospective evaluation of antibody response to Streptococcus gallolyticus and risk of colorectal cancer.
JO  - International journal of cancer
VL  - 143
IS  - 2
SN  - 0020-7136
CY  - Bognor Regis
PB  - Wiley-Liss
M1  - DKFZ-2018-00687
SP  - 245 - 252
PY  - 2018
AB  - The gut microbiome is increasingly implicated in colorectal cancer (CRC) development. A subgroup of patients diagnosed with CRC show high antibody responses to Streptococcus gallolyticus subspecies gallolyticus (SGG). However, it is unclear whether the association is also present pre-diagnostically. We assessed the association of antibody responses to SGG proteins in pre-diagnostic serum samples with CRC risk in a case-control study nested within a prospective cohort. Pre-diagnostic serum samples from 485 first incident CRC cases (mean time between blood draw and diagnosis 3.4 years) and 485 matched controls in the European Prospective Investigation into Nutrition and Cancer (EPIC) study were analyzed for antibody responses to 11 SGG proteins using multiplex serology. Odds ratios (OR) and 95
LB  - PUB:(DE-HGF)16
C6  - pmid:29377173
DO  - DOI:10.1002/ijc.31283
UR  - https://inrepo02.dkfz.de/record/135950
ER  -