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000136018 0247_ $$2doi$$a10.1016/j.celrep.2018.05.045
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000136018 1001_ $$0P:(DE-He78)b8cddb2a2d44b0f670d05b482f2a8b08$$aBormann, Felix$$b0$$eFirst author$$udkfz
000136018 245__ $$aCell-of-Origin DNA Methylation Signatures Are Maintained during Colorectal Carcinogenesis.
000136018 260__ $$aMaryland Heights, MO$$bCell Press$$c2018
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000136018 520__ $$aColorectal adenomas are precursor lesions of colorectal cancers and represent clonal amplifications of single cells from colonic crypts. DNA methylation patterns specify cell-type identity during cellular differentiation and, therefore, provide opportunities for the molecular analysis of tumors. We have now analyzed DNA methylation patterns in colorectal adenomas and identified three biologically defined subclasses that describe different intestinal crypt differentiation stages. Importantly, colorectal carcinomas could be classified into the same methylation subtypes, reflecting their shared cell types of origin with adenomas. Further data analysis also revealed significantly reduced overall survival for one of the subtypes. Our results provide a concept for understanding the methylation patterns observed in colorectal cancer and provide opportunities for tumor subclassification and patient stratification.
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000136018 7001_ $$0P:(DE-HGF)0$$aRodríguez-Paredes, Manuel$$b1
000136018 7001_ $$aLasitschka, Felix$$b2
000136018 7001_ $$0P:(DE-He78)92820b4867c955a04f642707ecf35b40$$aEdelmann, Dominic$$b3$$udkfz
000136018 7001_ $$0P:(DE-He78)8c6aa915aae944911892509166968bde$$aMusch, Tanja$$b4$$udkfz
000136018 7001_ $$0P:(DE-He78)e15dfa1260625c69d6690a197392a994$$aBenner, Axel$$b5$$udkfz
000136018 7001_ $$aBergman, Yehudit$$b6
000136018 7001_ $$0P:(DE-He78)34c336827b750ba10a020fd62ec4664f$$aDieter, Sebastian$$b7$$udkfz
000136018 7001_ $$0P:(DE-He78)7a10ea1b9b2872da9f375002c44ddfce$$aBall, Claudia$$b8$$udkfz
000136018 7001_ $$0P:(DE-He78)157277fe62f07df1732f9d126a51d1b9$$aGlimm, Hanno$$b9$$udkfz
000136018 7001_ $$0P:(DE-HGF)0$$aLinhart, Heinz G$$b10
000136018 7001_ $$0P:(DE-He78)a8d53a8cdc716390a6cbacdead227143$$aLyko, Frank$$b11$$eLast author$$udkfz
000136018 773__ $$0PERI:(DE-600)2649101-1$$a10.1016/j.celrep.2018.05.045$$gVol. 23, no. 11, p. 3407 - 3418$$n11$$p3407 - 3418$$tCell reports$$v23$$x2211-1247$$y2018
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