Journal Article

DKFZ-2018-00718

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Cell-of-Origin DNA Methylation Signatures Are Maintained during Colorectal Carcinogenesis.

Bormann, F. (First author)DKFZ* ; Rodríguez-Paredes, M.DKFZ* ; Lasitschka, F. ; Edelmann, D.DKFZ* ; Musch, T.DKFZ* ; Benner, A.DKFZ* ; Bergman, Y. ; Dieter, S.DKFZ* ; Ball, C.DKFZ* ; Glimm, H.DKFZ* ; Linhart, H. G.DKFZ* ; Lyko, F. (Last author)DKFZ*

2018
Cell Press Maryland Heights, MO

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Please use a persistent id in citations: doi:10.1016/j.celrep.2018.05.045

Abstract: Colorectal adenomas are precursor lesions of colorectal cancers and represent clonal amplifications of single cells from colonic crypts. DNA methylation patterns specify cell-type identity during cellular differentiation and, therefore, provide opportunities for the molecular analysis of tumors. We have now analyzed DNA methylation patterns in colorectal adenomas and identified three biologically defined subclasses that describe different intestinal crypt differentiation stages. Importantly, colorectal carcinomas could be classified into the same methylation subtypes, reflecting their shared cell types of origin with adenomas. Further data analysis also revealed significantly reduced overall survival for one of the subtypes. Our results provide a concept for understanding the methylation patterns observed in colorectal cancer and provide opportunities for tumor subclassification and patient stratification.

Note: DKFZ-ZMBH-Allianz

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Contributing Institute(s):

1. A130 Epigenetik (A130)
2. C060 Biostatistik (C060)
3. NCT DD Translationale Medizinische Onkologie (G911)
4. DKTK Dresden (L301)

Research Program(s):

1. 311 - Signalling pathways, cell and tumor biology (POF3-311) (POF3-311)

Appears in the scientific report 2018

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Database coverage:
; ; ; BIOSIS Previews ; DOAJ Seal ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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