TY  - JOUR
AU  - Bormann, Felix
AU  - Rodríguez-Paredes, Manuel
AU  - Lasitschka, Felix
AU  - Edelmann, Dominic
AU  - Musch, Tanja
AU  - Benner, Axel
AU  - Bergman, Yehudit
AU  - Dieter, Sebastian
AU  - Ball, Claudia
AU  - Glimm, Hanno
AU  - Linhart, Heinz G
AU  - Lyko, Frank
TI  - Cell-of-Origin DNA Methylation Signatures Are Maintained during Colorectal Carcinogenesis.
JO  - Cell reports
VL  - 23
IS  - 11
SN  - 2211-1247
CY  - Maryland Heights, MO
PB  - Cell Press
M1  - DKFZ-2018-00718
SP  - 3407 - 3418
PY  - 2018
N1  - DKFZ-ZMBH-Allianz
AB  - Colorectal adenomas are precursor lesions of colorectal cancers and represent clonal amplifications of single cells from colonic crypts. DNA methylation patterns specify cell-type identity during cellular differentiation and, therefore, provide opportunities for the molecular analysis of tumors. We have now analyzed DNA methylation patterns in colorectal adenomas and identified three biologically defined subclasses that describe different intestinal crypt differentiation stages. Importantly, colorectal carcinomas could be classified into the same methylation subtypes, reflecting their shared cell types of origin with adenomas. Further data analysis also revealed significantly reduced overall survival for one of the subtypes. Our results provide a concept for understanding the methylation patterns observed in colorectal cancer and provide opportunities for tumor subclassification and patient stratification.
LB  - PUB:(DE-HGF)16
C6  - pmid:29898408
DO  - DOI:10.1016/j.celrep.2018.05.045
UR  - https://inrepo02.dkfz.de/record/136018
ER  -