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@ARTICLE{Bormann:136018,
      author       = {F. Bormann$^*$ and M. Rodríguez-Paredes$^*$ and F.
                      Lasitschka and D. Edelmann$^*$ and T. Musch$^*$ and A.
                      Benner$^*$ and Y. Bergman and S. Dieter$^*$ and C. Ball$^*$
                      and H. Glimm$^*$ and H. G. Linhart$^*$ and F. Lyko$^*$},
      title        = {{C}ell-of-{O}rigin {DNA} {M}ethylation {S}ignatures {A}re
                      {M}aintained during {C}olorectal {C}arcinogenesis.},
      journal      = {Cell reports},
      volume       = {23},
      number       = {11},
      issn         = {2211-1247},
      address      = {Maryland Heights, MO},
      publisher    = {Cell Press},
      reportid     = {DKFZ-2018-00718},
      pages        = {3407 - 3418},
      year         = {2018},
      note         = {DKFZ-ZMBH-Allianz},
      abstract     = {Colorectal adenomas are precursor lesions of colorectal
                      cancers and represent clonal amplifications of single cells
                      from colonic crypts. DNA methylation patterns specify
                      cell-type identity during cellular differentiation and,
                      therefore, provide opportunities for the molecular analysis
                      of tumors. We have now analyzed DNA methylation patterns in
                      colorectal adenomas and identified three biologically
                      defined subclasses that describe different intestinal crypt
                      differentiation stages. Importantly, colorectal carcinomas
                      could be classified into the same methylation subtypes,
                      reflecting their shared cell types of origin with adenomas.
                      Further data analysis also revealed significantly reduced
                      overall survival for one of the subtypes. Our results
                      provide a concept for understanding the methylation patterns
                      observed in colorectal cancer and provide opportunities for
                      tumor subclassification and patient stratification.},
      cin          = {A130 / C060 / G911 / L301},
      ddc          = {570},
      cid          = {I:(DE-He78)A130-20160331 / I:(DE-He78)C060-20160331 /
                      I:(DE-He78)G911-20160331 / I:(DE-He78)L301-20160331},
      pnm          = {311 - Signalling pathways, cell and tumor biology
                      (POF3-311)},
      pid          = {G:(DE-HGF)POF3-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29898408},
      doi          = {10.1016/j.celrep.2018.05.045},
      url          = {https://inrepo02.dkfz.de/record/136018},
}