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@ARTICLE{Abubakar:136649,
      author       = {M. Abubakar and J. Chang-Claude$^*$ and H. R. Ali and N.
                      Chatterjee and P. Coulson and F. Daley and F. Blows and J.
                      Benitez and R. L. Milne and H. Brenner$^*$ and C. Stegmaier
                      and A. Mannermaa and A. Rudolph$^*$ and P. Sinn and F. J.
                      Couch and P. Devilee and R. A. E. M. Tollenaar and C.
                      Seynaeve and J. Figueroa and J. Lissowska and S. Hewitt and
                      M. J. Hooning and A. Hollestelle and R. Foekens and L. B.
                      Koppert and k. Investigators and M. K. Bolla and Q. Wang and
                      M. E. Jones and M. J. Schoemaker and R. Keeman and D. F.
                      Easton and A. J. Swerdlow and M. E. Sherman and M. K.
                      Schmidt and P. D. Pharoah and M. Garcia-Closas},
      title        = {{E}tiology of hormone receptor positive breast cancer
                      differs by levels of histologic grade and proliferation.},
      journal      = {International journal of cancer},
      volume       = {143},
      number       = {4},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2018-01118},
      pages        = {746 - 757},
      year         = {2018},
      abstract     = {Limited epidemiological evidence suggests that the etiology
                      of hormone receptor positive (HR+) breast cancer may differ
                      by levels of histologic grade and proliferation. We pooled
                      risk factor and pathology data on 5,905 HR+ breast cancer
                      cases and 26,281 controls from 11 epidemiological studies.
                      Proliferation was determined by centralized automated
                      measures of KI67 in tissue microarrays. Odds ratios (OR),
                      $95\%$ confidence intervals (CI) and p-values for case-case
                      and case-control comparisons for risk factors in relation to
                      levels of grade and quartiles (Q1-Q4) of KI67 were estimated
                      using polytomous logistic regression models. Case-case
                      comparisons showed associations between nulliparity and high
                      KI67 [OR $(95\%$ CI) for Q4 vs. Q1 = 1.54 (1.22, 1.95)];
                      obesity and high grade [grade 3 vs. 1 = 1.68 (1.31,
                      2.16)] and current use of combined hormone therapy (HT) and
                      low grade [grade 3 vs. 1 = 0.27 (0.16, 0.44)] tumors. In
                      case-control comparisons, nulliparity was associated with
                      elevated risk of tumors with high but not low levels of
                      proliferation [1.43 (1.14, 1.81) for KI67 Q4 vs. 0.83 (0.60,
                      1.14) for KI67 Q1]; obesity among women ≥50 years with
                      high but not low grade tumors [1.55 (1.17, 2.06) for grade 3
                      vs. 0.88 (0.66, 1.16) for grade 1] and HT with low but not
                      high grade tumors [3.07 (2.22, 4.23) for grade 1 vs. 0.85
                      (0.55, 1.30) for grade 3]. Menarcheal age and family history
                      were similarly associated with HR+ tumors of different grade
                      or KI67 levels. These findings provide insights into the
                      etiologic heterogeneity of HR+ tumors.},
      cin          = {C020 / C070 / G110 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)G110-20160331 / I:(DE-He78)L101-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29492969},
      pmc          = {pmc:PMC6041155},
      doi          = {10.1002/ijc.31352},
      url          = {https://inrepo02.dkfz.de/record/136649},
}