Journal Article

DKFZ-2018-01118

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Etiology of hormone receptor positive breast cancer differs by levels of histologic grade and proliferation.

Abubakar, M. ; Chang-Claude, J.DKFZ* ; Ali, H. R. ; Chatterjee, N. ; Coulson, P. ; Daley, F. ; Blows, F. ; Benitez, J. ; Milne, R. L. ; Brenner, H.DKFZ* ; Stegmaier, C. ; Mannermaa, A. ; Rudolph, A.DKFZ* ; Sinn, P. ; Couch, F. J. ; Devilee, P. ; Tollenaar, R. A. E. M. ; Seynaeve, C. ; Figueroa, J. ; Lissowska, J. ; Hewitt, S. ; Hooning, M. J. ; Hollestelle, A. ; Foekens, R. ; Koppert, L. B. ; Investigators, k. ; Bolla, M. K. ; Wang, Q. ; Jones, M. E. ; Schoemaker, M. J. ; Keeman, R. ; Easton, D. F. ; Swerdlow, A. J. ; Sherman, M. E. ; Schmidt, M. K. ; Pharoah, P. D. ; Garcia-Closas, M.

2018
Wiley-Liss Bognor Regis

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Please use a persistent id in citations: doi:10.1002/ijc.31352

Abstract: Limited epidemiological evidence suggests that the etiology of hormone receptor positive (HR+) breast cancer may differ by levels of histologic grade and proliferation. We pooled risk factor and pathology data on 5,905 HR+ breast cancer cases and 26,281 controls from 11 epidemiological studies. Proliferation was determined by centralized automated measures of KI67 in tissue microarrays. Odds ratios (OR), 95% confidence intervals (CI) and p-values for case-case and case-control comparisons for risk factors in relation to levels of grade and quartiles (Q1-Q4) of KI67 were estimated using polytomous logistic regression models. Case-case comparisons showed associations between nulliparity and high KI67 [OR (95% CI) for Q4 vs. Q1 = 1.54 (1.22, 1.95)]; obesity and high grade [grade 3 vs. 1 = 1.68 (1.31, 2.16)] and current use of combined hormone therapy (HT) and low grade [grade 3 vs. 1 = 0.27 (0.16, 0.44)] tumors. In case-control comparisons, nulliparity was associated with elevated risk of tumors with high but not low levels of proliferation [1.43 (1.14, 1.81) for KI67 Q4 vs. 0.83 (0.60, 1.14) for KI67 Q1]; obesity among women ≥50 years with high but not low grade tumors [1.55 (1.17, 2.06) for grade 3 vs. 0.88 (0.66, 1.16) for grade 1] and HT with low but not high grade tumors [3.07 (2.22, 4.23) for grade 1 vs. 0.85 (0.55, 1.30) for grade 3]. Menarcheal age and family history were similarly associated with HR+ tumors of different grade or KI67 levels. These findings provide insights into the etiologic heterogeneity of HR+ tumors.

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)
2. C070 Klinische Epidemiologie und Alternf. (C070)
3. Präventive Onkologie (G110)
4. DKTK Heidelberg (L101)

Research Program(s):

1. 313 - Cancer risk factors and prevention (POF3-313) (POF3-313)

Appears in the scientific report 2018

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Database coverage:
; BIOSIS Previews ; Current Contents - Life Sciences ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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