TY  - JOUR
AU  - Neumeyer, Sonja Maria
AU  - Banbury, Barbara L
AU  - Arndt, Volker
AU  - Berndt, Sonja I
AU  - Bezieau, Stephane
AU  - Bien, Stephanie A
AU  - Buchanan, Dan D
AU  - Butterbach, Katja
AU  - Caan, Bette J
AU  - Campbell, Peter T
AU  - Casey, Graham
AU  - Chan, Andrew T
AU  - Chanock, Stephen J
AU  - Dai, James Y
AU  - Gallinger, Steven
AU  - Giovannucci, Edward L
AU  - Giles, Graham G
AU  - Grady, William M
AU  - Hampe, Jochen
AU  - Hoffmeister, Michael
AU  - Hopper, John L
AU  - Hsu, Li
AU  - Jenkins, Mark A
AU  - Joshi, Amit
AU  - Larsson, Susanna C
AU  - Le Marchand, Loic
AU  - Lindblom, Annika
AU  - Moreno, Victor
AU  - Lemire, Mathieu
AU  - Li, Li
AU  - Lin, Yi
AU  - Offit, Kenneth
AU  - Newcomb, Polly A
AU  - Pharaoh, Paul D
AU  - Potter, John D
AU  - Qi, Lihong
AU  - Rennert, Gad
AU  - Schafmayer, Clemens
AU  - Schoen, Robert E
AU  - Slattery, Martha L
AU  - Song, Mingyang
AU  - Ulrich, Cornelia M
AU  - Win, Aung K
AU  - White, Emily
AU  - Wolk, Alicja
AU  - Woods, Michael O
AU  - Wu, Anna H
AU  - Gruber, Stephen B
AU  - Brenner, Hermann
AU  - Peters, Ulrike
AU  - Chang-Claude, Jenny
TI  - Mendelian randomisation study of age at menarche and age at menopause and the risk of colorectal cancer.
JO  - British journal of cancer
VL  - 118
IS  - 12
SN  - 1532-1827
CY  - Edinburgh
PB  - Nature Publ. Group
M1  - DKFZ-2018-01211
SP  - 1639 - 1647
PY  - 2018
AB  - Substantial evidence supports an association between use of menopausal hormone therapy and decreased colorectal cancer (CRC) risk, indicating a role of exogenous sex hormones in CRC development. However, findings on endogenous oestrogen exposure and CRC are inconsistent.We used a Mendelian randomisation approach to test for a causal effect of age at menarche and age at menopause as surrogates for endogenous oestrogen exposure on CRC risk. Weighted genetic risk scores based on 358 single-nucleotide polymorphisms associated with age at menarche and 51 single-nucleotide polymorphisms associated with age at menopause were used to estimate the association with CRC risk using logistic regression in 12,944 women diagnosed with CRC and 10,741 women without CRC from three consortia. Sensitivity analyses were conducted to address pleiotropy and possible confounding by body mass index.Genetic risk scores for age at menarche (odds ratio per year 0.98, 95
LB  - PUB:(DE-HGF)16
C6  - pmid:29795306
C2  - pmc:PMC6008474
DO  - DOI:10.1038/s41416-018-0108-8
UR  - https://inrepo02.dkfz.de/record/136773
ER  -