Journal Article

DKFZ-2018-01211

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Mendelian randomisation study of age at menarche and age at menopause and the risk of colorectal cancer.

Neumeyer, S. M. (First author)DKFZ* ; Banbury, B. L. ; Arndt, V.DKFZ* ; Berndt, S. I. ; Bezieau, S. ; Bien, S. A. ; Buchanan, D. D. ; Butterbach, K.DKFZ* ; Caan, B. J. ; Campbell, P. T. ; Casey, G. ; Chan, A. T. ; Chanock, S. J. ; Dai, J. Y. ; Gallinger, S. ; Giovannucci, E. L. ; Giles, G. G. ; Grady, W. M. ; Hampe, J. ; Hoffmeister, M.DKFZ* ; Hopper, J. L. ; Hsu, L. ; Jenkins, M. A. ; Joshi, A. ; Larsson, S. C. ; Le Marchand, L. ; Lindblom, A. ; Moreno, V. ; Lemire, M. ; Li, L. ; Lin, Y. ; Offit, K. ; Newcomb, P. A. ; Pharaoh, P. D. ; Potter, J. D. ; Qi, L. ; Rennert, G. ; Schafmayer, C. ; Schoen, R. E. ; Slattery, M. L. ; Song, M. ; Ulrich, C. M. ; Win, A. K. ; White, E. ; Wolk, A. ; Woods, M. O. ; Wu, A. H. ; Gruber, S. B. ; Brenner, H.DKFZ* ; Peters, U. ; Chang-Claude, J. (Last author)DKFZ*

2018
Nature Publ. Group Edinburgh

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Please use a persistent id in citations: doi:10.1038/s41416-018-0108-8

Abstract: Substantial evidence supports an association between use of menopausal hormone therapy and decreased colorectal cancer (CRC) risk, indicating a role of exogenous sex hormones in CRC development. However, findings on endogenous oestrogen exposure and CRC are inconsistent.We used a Mendelian randomisation approach to test for a causal effect of age at menarche and age at menopause as surrogates for endogenous oestrogen exposure on CRC risk. Weighted genetic risk scores based on 358 single-nucleotide polymorphisms associated with age at menarche and 51 single-nucleotide polymorphisms associated with age at menopause were used to estimate the association with CRC risk using logistic regression in 12,944 women diagnosed with CRC and 10,741 women without CRC from three consortia. Sensitivity analyses were conducted to address pleiotropy and possible confounding by body mass index.Genetic risk scores for age at menarche (odds ratio per year 0.98, 95% confidence interval: 0.95-1.02) and age at menopause (odds ratio 0.98, 95% confidence interval: 0.94-1.01) were not significantly associated with CRC risk. The sensitivity analyses yielded similar results.Our study does not support a causal relationship between genetic risk scores for age at menarche and age at menopause and CRC risk.

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)
2. C070 Klinische Epidemiologie und Alternf. (C070)
3. Präventive Onkologie (G110)
4. DKTK Heidelberg (L101)

Research Program(s):

1. 313 - Cancer risk factors and prevention (POF3-313) (POF3-313)

Appears in the scientific report 2018

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Database coverage:
; BIOSIS Previews ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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