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@ARTICLE{Neumeyer:136773,
      author       = {S. M. Neumeyer$^*$ and B. L. Banbury and V. Arndt$^*$ and
                      S. I. Berndt and S. Bezieau and S. A. Bien and D. D.
                      Buchanan and K. Butterbach$^*$ and B. J. Caan and P. T.
                      Campbell and G. Casey and A. T. Chan and S. J. Chanock and
                      J. Y. Dai and S. Gallinger and E. L. Giovannucci and G. G.
                      Giles and W. M. Grady and J. Hampe and M. Hoffmeister$^*$
                      and J. L. Hopper and L. Hsu and M. A. Jenkins and A. Joshi
                      and S. C. Larsson and L. Le Marchand and A. Lindblom and V.
                      Moreno and M. Lemire and L. Li and Y. Lin and K. Offit and
                      P. A. Newcomb and P. D. Pharaoh and J. D. Potter and L. Qi
                      and G. Rennert and C. Schafmayer and R. E. Schoen and M. L.
                      Slattery and M. Song and C. M. Ulrich and A. K. Win and E.
                      White and A. Wolk and M. O. Woods and A. H. Wu and S. B.
                      Gruber and H. Brenner$^*$ and U. Peters and J.
                      Chang-Claude$^*$},
      title        = {{M}endelian randomisation study of age at menarche and age
                      at menopause and the risk of colorectal cancer.},
      journal      = {British journal of cancer},
      volume       = {118},
      number       = {12},
      issn         = {1532-1827},
      address      = {Edinburgh},
      publisher    = {Nature Publ. Group},
      reportid     = {DKFZ-2018-01211},
      pages        = {1639 - 1647},
      year         = {2018},
      abstract     = {Substantial evidence supports an association between use of
                      menopausal hormone therapy and decreased colorectal cancer
                      (CRC) risk, indicating a role of exogenous sex hormones in
                      CRC development. However, findings on endogenous oestrogen
                      exposure and CRC are inconsistent.We used a Mendelian
                      randomisation approach to test for a causal effect of age at
                      menarche and age at menopause as surrogates for endogenous
                      oestrogen exposure on CRC risk. Weighted genetic risk scores
                      based on 358 single-nucleotide polymorphisms associated with
                      age at menarche and 51 single-nucleotide polymorphisms
                      associated with age at menopause were used to estimate the
                      association with CRC risk using logistic regression in
                      12,944 women diagnosed with CRC and 10,741 women without CRC
                      from three consortia. Sensitivity analyses were conducted to
                      address pleiotropy and possible confounding by body mass
                      index.Genetic risk scores for age at menarche (odds ratio
                      per year 0.98, $95\%$ confidence interval: 0.95-1.02) and
                      age at menopause (odds ratio 0.98, $95\%$ confidence
                      interval: 0.94-1.01) were not significantly associated with
                      CRC risk. The sensitivity analyses yielded similar
                      results.Our study does not support a causal relationship
                      between genetic risk scores for age at menarche and age at
                      menopause and CRC risk.},
      cin          = {C020 / C070 / G110 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)G110-20160331 / I:(DE-He78)L101-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29795306},
      pmc          = {pmc:PMC6008474},
      doi          = {10.1038/s41416-018-0108-8},
      url          = {https://inrepo02.dkfz.de/record/136773},
}