% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Schumacher:136806,
      author       = {F. R. Schumacher and A. A. Al Olama and S. I. Berndt and S.
                      Benlloch and M. Ahmed and E. J. Saunders and T. Dadaev and
                      D. Leongamornlert and E. Anokian and C. Cieza-Borrella and
                      C. Goh and M. N. Brook and X. Sheng and L. Fachal and J.
                      Dennis and J. Tyrer and K. Muir and A. Lophatananon and V.
                      L. Stevens and S. M. Gapstur and B. D. Carter and C. M.
                      Tangen and P. J. Goodman and I. M. Thompson and J. Batra and
                      S. Chambers and L. Moya and J. Clements and L. Horvath and
                      W. Tilley and G. P. Risbridger and H. Gronberg and M. Aly
                      and T. Nordström and P. Pharoah and N. Pashayan and J.
                      Schleutker and T. L. J. Tammela and C. Sipeky and A. Auvinen
                      and D. Albanes and S. Weinstein and A. Wolk and N.
                      Håkansson and C. M. L. West and A. M. Dunning and N. Burnet
                      and L. A. Mucci and E. Giovannucci and G. L. Andriole and O.
                      Cussenot and G. Cancel-Tassin and S. Koutros and L. E. Beane
                      Freeman and K. D. Sorensen and T. F. Orntoft and M. Borre
                      and L. Maehle and E. M. Grindedal and D. E. Neal and J. L.
                      Donovan and F. C. Hamdy and R. M. Martin and R. C. Travis
                      and T. J. Key and R. J. Hamilton and N. E. Fleshner and A.
                      Finelli and S. A. Ingles and M. C. Stern and B. S.
                      Rosenstein and S. L. Kerns and H. Ostrer and Y.-J. Lu and
                      H.-W. Zhang and N. Feng and X. Mao and X. Guo and G. Wang
                      and Z. Sun and G. G. Giles and M. C. Southey and R. J.
                      MacInnis and L. M. FitzGerald and A. S. Kibel and B. F.
                      Drake and A. Vega and A. Gómez-Caamaño and R. Szulkin and
                      M. Eklund and M. Kogevinas and J. Llorca and G.
                      Castaño-Vinyals and K. L. Penney and M. Stampfer and J. Y.
                      Park and T. A. Sellers and H.-Y. Lin and J. L. Stanford and
                      C. Cybulski and D. Wokolorczyk and J. Lubinski and E. A.
                      Ostrander and M. S. Geybels and B. G. Nordestgaard and S. F.
                      Nielsen and M. Weischer and R. Bisbjerg and M. A. Røder and
                      P. Iversen and H. Brenner$^*$ and K. Cuk$^*$ and B.
                      Holleczek and C. Maier and M. Luedeke and T. Schnoeller and
                      J. Kim and C. J. Logothetis and E. M. John and M. R.
                      Teixeira and P. Paulo and M. Cardoso and S. L. Neuhausen and
                      L. Steele and Y. C. Ding and K. De Ruyck and G. De Meerleer
                      and P. Ost and A. Razack and J. Lim and S.-H. Teo and D. W.
                      Lin and L. F. Newcomb and D. Lessel and M. Gamulin and T.
                      Kulis and R. Kaneva and N. Usmani and S. Singhal and C.
                      Slavov and V. Mitev and M. Parliament and F. Claessens and
                      S. Joniau and T. Van den Broeck and S. Larkin and P. A.
                      Townsend and C. Aukim-Hastie and M. G. Dominguez and J. E.
                      Castelao and M. E. Martinez and M. J. Roobol and G. Jenster
                      and R. H. N. van Schaik and F. Menegaux and T. Truong and Y.
                      A. Koudou and J. Xu and K.-T. Khaw and L. Cannon-Albright
                      and H. Pandha and A. Michael and S. N. Thibodeau and S. K.
                      McDonnell and D. J. Schaid and S. Lindstrom and C. Turman
                      and J. Ma and D. J. Hunter and E. Riboli and A. Siddiq and
                      F. Canzian$^*$ and L. N. Kolonel and L. Le Marchand and R.
                      N. Hoover and M. J. Machiela and Z. Cui and P. Kraft and C.
                      I. Amos and D. V. Conti and D. F. Easton and F. Wiklund and
                      S. J. Chanock and B. E. Henderson and Z. Kote-Jarai and C.
                      A. Haiman and R. A. Eeles},
      collaboration = {P. Study and A. P. C. BioResource and I. Study and C. P.
                      Investigators and B. a. P. C. C. Consortium and PRACTICAL
                      and C. o. t. P. i. Sweden and P. C. G. A. S. o. U. S. Loci
                      and G. A. a. M. i. Oncology},
      title        = {{A}ssociation analyses of more than 140,000 men identify 63
                      new prostate cancer susceptibility loci.},
      journal      = {Nature genetics},
      volume       = {50},
      number       = {7},
      issn         = {1546-1718},
      address      = {New York, NY},
      publisher    = {Nature America},
      reportid     = {DKFZ-2018-01244},
      pages        = {928 - 936},
      year         = {2018},
      abstract     = {Genome-wide association studies (GWAS) and fine-mapping
                      efforts to date have identified more than 100 prostate
                      cancer (PrCa)-susceptibility loci. We meta-analyzed genotype
                      data from a custom high-density array of 46,939 PrCa cases
                      and 27,910 controls of European ancestry with previously
                      genotyped data of 32,255 PrCa cases and 33,202 controls of
                      European ancestry. Our analysis identified 62 novel loci
                      associated (P < 5.0 × 10-8) with PrCa and one locus
                      significantly associated with early-onset PrCa (≤55
                      years). Our findings include missense variants rs1800057
                      (odds ratio (OR) = 1.16; P = 8.2 × 10-9; G>C,
                      p.Pro1054Arg) in ATM and rs2066827 (OR = 1.06;
                      P = 2.3 × 10-9; T>G, p.Val109Gly) in CDKN1B. The
                      combination of all loci captured $28.4\%$ of the PrCa
                      familial relative risk, and a polygenic risk score conferred
                      an elevated PrCa risk for men in the ninetieth to
                      ninety-ninth percentiles (relative risk = 2.69; $95\%$
                      confidence interval (CI): 2.55-2.82) and first percentile
                      (relative risk = 5.71; $95\%$ CI: 5.04-6.48) risk
                      stratum compared with the population average. These findings
                      improve risk prediction, enhance fine-mapping, and provide
                      insight into the underlying biology of PrCa1.},
      cin          = {C070 / C055},
      ddc          = {570},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C055-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29892016},
      doi          = {10.1038/s41588-018-0142-8},
      url          = {https://inrepo02.dkfz.de/record/136806},
}