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000136962 041__ $$aeng
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000136962 1001_ $$aMetcalfe, Alan J$$b0
000136962 245__ $$aAcute and chronic effects of exercise on the kynurenine pathway in humans - A brief review and future perspectives.
000136962 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2018
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000136962 520__ $$aTryptophan (TRP) is an essential amino acid. Metabolites of TRP have been identified as important mediators in immune regulation and function of the central nervous system. Inflammation strongly stimulates to the breakdown of TRP into Kynurenine (KYN), representing the initial step of the KYN pathway. Recently, exercise interventions have been able to demonstrate a modification of the KYN pathway plausibly by altering inflammation. However, modifications differ between acute and chronic exercise interventions. As such, this review examines the current studies that have investigated the effect of an acute (single bout) or chronic (training) exercise intervention on levels of TRP and KYN in both healthy and diseased populations.
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000136962 7001_ $$aKoliamitra, Christina$$b1
000136962 7001_ $$aJavelle, Florian$$b2
000136962 7001_ $$aBloch, Wilhelm$$b3
000136962 7001_ $$0P:(DE-He78)d05b24af674d8ef2c455634434b67770$$aZimmer, Philipp$$b4$$eLast author$$udkfz
000136962 773__ $$0PERI:(DE-600)2008755-X$$a10.1016/j.physbeh.2018.07.015$$gVol. 194, p. 583 - 587$$p583 - 587$$tPhysiology & behavior$$v194$$x0031-9384$$y2018
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